Serum Neutrophil Gelatinase- Associated Lipocalin as a Marker of Malnutrition in Maintenance Hemodialyzed Patients
Abd AlRahman, A., Esaa, H., Ahmad, E., Mohammed, S. (2021). Serum Neutrophil Gelatinase- Associated Lipocalin as a Marker of Malnutrition in Maintenance Hemodialyzed Patients. EKB Journal Management System, 38(1), 169-184. doi: 10.21608/bmfj.2020.120492
Anas Abd AlRahman; Hesham Esaa; Enas Ahmad; Seham Mohammed. "Serum Neutrophil Gelatinase- Associated Lipocalin as a Marker of Malnutrition in Maintenance Hemodialyzed Patients". EKB Journal Management System, 38, 1, 2021, 169-184. doi: 10.21608/bmfj.2020.120492
Abd AlRahman, A., Esaa, H., Ahmad, E., Mohammed, S. (2021). 'Serum Neutrophil Gelatinase- Associated Lipocalin as a Marker of Malnutrition in Maintenance Hemodialyzed Patients', EKB Journal Management System, 38(1), pp. 169-184. doi: 10.21608/bmfj.2020.120492
Abd AlRahman, A., Esaa, H., Ahmad, E., Mohammed, S. Serum Neutrophil Gelatinase- Associated Lipocalin as a Marker of Malnutrition in Maintenance Hemodialyzed Patients. EKB Journal Management System, 2021; 38(1): 169-184. doi: 10.21608/bmfj.2020.120492

Serum Neutrophil Gelatinase- Associated Lipocalin as a Marker of Malnutrition in Maintenance Hemodialyzed Patients

Benha Medical Journal
Article 15, Volume 38, Issue 1, April 2021, Page 169-184  XML PDF (682.69 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.120492
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Authors
Anas Abd AlRahman; Hesham Esaa; Enas Ahmad; Seham Mohammed
Department of clinical and chemical pathology, Faculty of Medicine, Benha University, Egypt.
Abstract
Background: Neutrophil Gelatinase- Associated Lipocalin (NGAL) is a useful clinical biomarker for early diagnosis, predicting disease severity, therapeutic monitoring, and for predicting clinical outcomes. Aim: The current study aimed to investigate  serum   Neutrophil gelatinase-associated lipocalin ( NGAL ) levels as a marker of malnutrition in maintenance hemodialysis patients. Subjects and methods: This study was conducted on 50 subjects. Subjects were divided into three groups .Group (1): Hemodialyzed patients : Included 30 patients before starting hemodialysis (HD). Group (2):  The same 30 patients after hemodialysis. Group (3): Included control group. Serum levels of NGAL was measured by  enzyme-linked immunosorbent assay (ELISA ). Results: There is high statistically significant decrease in NGAL in dialyzed patients after dialysis when compared to the same patients before dialysis (p < 0.001). There is  statistically significant positive correlation between NGAL after dialysis and albumin, pre-albumin, serum iron, serum ferritin, TLC and neutrophils %. There is a statistically significant decrease in the serum level of NGAL (before and after) in dialysis patients with malnutrition  when compared to ( before and after )  dialysis patients without  malnutrition. Conclusion: Serum level of NGAL seems to be a reliable marker of malnutrition appearance, allowing early diagnosis and preventive therapy.
Keywords
Neutrophil Gelatinase Associated Lipocalin (NGAL); malnutrition; hemodialysis
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