Microbial Infections in Immunodeficient Children in Qena University Hospital with Special Reference to DNA Damage in Peripheral Blood Leucocytes | ||||
SVU-International Journal of Medical Sciences | ||||
Article 6, Volume 1, Issue 1, July 2018, Page 23-31 PDF (191.93 K) | ||||
Document Type: Original research articles | ||||
DOI: 10.21608/svuijm.2018.120561 | ||||
View on SCiNiTO | ||||
Authors | ||||
Mona M. Mohamed* 1; Mohammed B. EL-Mahdy2; Ahmed EL-Abd Ahmed3; Mohammed A. El-Feky4 | ||||
1Microbiology Department, Faculty of Medicine, South Valley University, Qena, Egypt | ||||
2Zoology Department, Faculty of Science, South Valley University, Qena, Egypt | ||||
3Pediatric Department, Faculty of Medicine, South Valley University, Qena, Egypt | ||||
4Microbiology Department , Faculty of Medicine, Assuit University, Assiut, Egypt | ||||
Abstract | ||||
Background: Immunodeficiency disorders involve malfunction of the immune system, resulting in infections that develop and recur more frequently, are more severe, and last longer than usual, Impair the immune system's ability to defend the body against foreign or abnormal cells that invade or attack it (such as bacteria, viruses, fungi, and cancer cells). As a result, unusual bacterial, viral, or fungal infections or lymphomas or other cancers may develop. Patients and methods: A study to detect blood stream infections was done using 100 blood cultures obtained from 100 immunocompromised children. Results and conclusions: The most commonly isolated are bacterial organism (40 %)the most common bacterial isolates are klebsiella species (17 | 40 ,42.5%). Estimation of DNA damage was done for 40 patients and 10 apparently healthy children as control subjects. The DNA damage was detected has took the smear shape on gel electrophoresis. This was found in (12|40, 30%), (P value < 0.001) with significant difference. | ||||
Keywords | ||||
Infections; DNA damage; Immunodeficiency; Qena | ||||
Statistics Article View: 168 PDF Download: 541 |
||||