Effect of combined treatment with cryotherapy plus chemo- radiotherapy versus chemo- radiotherapy alone in a non-small-cell lung cancer | ||||
SVU-International Journal of Medical Sciences | ||||
Article 10, Volume 1, Issue 1, July 2018, Page 54-59 PDF (167.91 K) | ||||
Document Type: Original research articles | ||||
DOI: 10.21608/svuijm.2018.120565 | ||||
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Authors | ||||
Mohamed S. Badawy1; Alaa R. Mahmoud2; Mohammed M. Ali3; Haggagy Mansour* 2 | ||||
1Department of Chest Diseases, Faculty of Medicine, Luxur University, Luxor, Egypt | ||||
2Department of Chest Disease, Qena faculty of medicine, South Valley University, Qena, Egypt | ||||
3Department of Oncology, Qena faculty of medicine, South Valley University, Qena, Egypt | ||||
Abstract | ||||
Background:In end-stage patients when all management options have been used, will often develop compromise of their airways as the cancer continues to progress. Endobronchial therapy options may help to relieve some of their symptoms, allowing improvement in their shortness of breath as they go home in combination with other palliative therapies. Objective: To compare the safety; efficacy; and clinical outcome of endobronchialcryotherapy combined with chemotherapy and/ or radiotherapy versus chemo-radiotherapy alone on patients with Non-small cell lung cancer. Patients and method(s): A prospective randomized clinical trial was carried out on 60 patients, diagnosed as bronchogenic carcinoma non-small cell lung cancer type (NSCLC). The patients attended the hospital in the chest department, Qena Faculty of Medicine, South Valley University. Assessment of the patients was done and randomly assigned into two groups.Group1, Include 30 patients subjected to chemotherapy, radiotherapy and endobronchialcryotherapy.Group2 ,Include include 30 patients subjected to chemotherapy and radiotherapy alone. Result(s): There was significant response meat in symptomatology in Group (1) cryotherapy with regard to cough (P value .000) , dyspnea (P value .000) and haemoptysis (P value .000) . Also, from the functional point of view, in group 1 there were significant improvement to cryotherapy was achieved in FVC(P value .000) , FEV1 (P value .000) , PEFR (P value .000) , and 6MWT (P value .000) . However, there were no significant difference in group 2 between the incidence of improvement in FVC , FEV1 , PEFR , and 6MWT. Conclusion:There wasbenifical effect of combination of endobronchialcryotherapy to patients with lung cancer plus chemo and/ or radiotherapy in the form of improved symptoms and lung functions. | ||||
Keywords | ||||
non-small cell lung cancer; cryotherapy; symptomatology; lung function | ||||
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