The effects of oral ketoconazole and griseofulvin on the fertility of male rabbits | ||||
| Mansoura Veterinary Medical Journal | ||||
| Article 1, Volume 21, Issue 2, June 2020, Page 32-38 PDF (1.56 MB) | ||||
| Document Type: Original Articles | ||||
| DOI: 10.21608/mvmj.2020.21.2.0203 | ||||
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| Authors | ||||
| Amal Mohamed1; Aza Hassan1; Magdy Amer2; El-Said Abdel-Aziz3 | ||||
| 1Animal Health Research Institute, Mansoura, Egypt | ||||
| 2Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, P.O 35516, Egypt | ||||
| 3Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Objectives: To investigate possible side effects of ketoconazole and griseofulvin on fertility of clinically healthy male rabbits. Design: Randomized controlled experimental study. Animals: Thirty mature male rabbits. Procedures: Rabbits were randomly allocated into three equal sized groups (10 animals each). The first group served as a control group (received no treatment), the second group received griseofulvin (25 mg/kg B.W) orally for 30 days, and the third group received ketoconazole (50 mg/kg B.W) orally for 30 days. Semen samples were collected after 1 day, 1 week and 2 weeks post-administration to determine sperm motility, % of live and dead sperms, total sperm abnormalities and sperm cell concentration. Two weeks post-administration, testes and epididymides were removed for histopathological examination. Results: Both drugs produced a significant reduction in the serum testosterone level, sperm cell concentration, percent of live sperms and percent of sperm motility. Conclusion and clinical relevance: Ketoconazole and griseofulvin have a negative impact on fertility of male rabbits, and the effect is more pronounced with ketoconazole. | ||||
| Keywords | ||||
| Ketoconazole; Griseofulvin; Fertility; Rabbit | ||||
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