Histological Structure of Pancreas in Chronic Pancreatitis and The Role of Pancreatic Stellate Cells | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 19, Volume 81, Issue 4, October 2020, Page 1835-1839 PDF (934.19 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2020.121008 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ghada Hamed Hasan Romeh  ; Fatma El-Nabawia Abdel-Hady El-Safty; Abeer El-Said El-Mehi, Manar Ali Faried
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| Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Menoufia, Egypt | ||||
| Abstract | ||||
| Background: Chronic pancreatitis is a progressive inflammatory disease that causes damage and fibrosis of the parenchyma of pancreas, thus leads to endocrine and exocrine dysfunction. Objective: The goals of this review were to analyze morphological alterations in pancreatic tissue during chronic pancreatitis and this analysis addresses the effect of pancreatic stellate cells (PSCs), on chronic pancreatitis, and collagen fiber deposition. Results: This review also discussed the different immunohistochemical markers for PSCs. Alpha smooth muscle actin (α-SMA) is an excellent marker for activated PSCs. Transforming growth factor beta (TGFβ) is an important profibrogenic cytokine that appears to act by stimulating collagen production by PSCs. Conclusion: It was concluded that chronic pancreatitis caused a significant and progressive serious effects on the acinar cells, duct system, and islets of Langerhans in the form of intracellular vacuolations, decreased zymogen granules, pyknotic nuclei and thickening of the duct wall, and extensive fibrosis. It is hypothesised that during pancreatic injury, PSCs are activated and proliferated exhibiting positive staining for the cytoskeletal protein α- SMA, and synthesising amounts of extracellular matrix proteins, particularly collagen. | ||||
| Keywords | ||||
| Chronic pancreatitis; pancreatic stellate cells; fibrosis | ||||
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