Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis
Ismaiel, W., Ibrahim, A., Mohammed, S. (2021). Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis. EKB Journal Management System, 3(2), 1200-1207. doi: 10.21608/ijma.2020.42597.1166
Wael Fawzy Ismaiel; Ahmed Abd Alrahman Ibrahim; Sami Abdullah Mohammed. "Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis". EKB Journal Management System, 3, 2, 2021, 1200-1207. doi: 10.21608/ijma.2020.42597.1166
Ismaiel, W., Ibrahim, A., Mohammed, S. (2021). 'Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis', EKB Journal Management System, 3(2), pp. 1200-1207. doi: 10.21608/ijma.2020.42597.1166
Ismaiel, W., Ibrahim, A., Mohammed, S. Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis. EKB Journal Management System, 2021; 3(2): 1200-1207. doi: 10.21608/ijma.2020.42597.1166

Comparative Histopathological Changes Between Primary Versus Recurrent Rhinosinusitis with Nasal Polyposis

International Journal of Medical Arts
Article 6, Volume 3, Issue 2, April 2021, Page 1200-1207  XML PDF (1.43 MB)
Document Type: Original Article
DOI: 10.21608/ijma.2020.42597.1166
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Authors
Wael Fawzy Ismaiel email 1; Ahmed Abd Alrahman Ibrahim2; Sami Abdullah Mohammed3
1Department of Otorhinolaryngology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
2Department of Otorhinolarygology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
3Department of Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
Abstract
Background: Chronic rhinosinusitis associated with nasal polypi [CRSwNP] is one of the two major chronic rhinosinusitis phenotypes. The histopathological changes of such condition may differ between primary and chronic types.
Aim of the work: To differentiate between primary and chronic rhinosinusitis with polypi through detection of the histopathological changes of nasal mucosa.
Patients and Methods: Eighty-five patients with CRSwNP scheduled for functional endoscopic sinus surgery (FESS) were divided into two groups; group (1) 35 patients with primary polyposis, group (2) 50 patients with chronic polyposis. A swab was taken from sinus mucosa during FESS and sent for histopathological investigation.
Results: We studied 12 histopathogical findings of spacemen of sinus mucosa and found 7 of them had a significant value in comparison between primary and recurrent CRSwNP. The significant increases in chronic recurrent group (2) than primary group (1) were eosinophilic cell count (p=0.044), eosinophilic cell aggregation (p=0.049), basement membrane thickness (P=0.021), Mucosal ulceration (p=0.002), hyperplastic or papillary change (p=0.029), fibrosis (p=0.002) and fungal element (p=0.003).
Conclusion: Histopathological findings of sinus mucosa during FESS operation found to be of great value in differentiating between primary and recurrent CRSwNP, however, further studies on large scale groups were recommended to confirm these results.
Keywords
Rhinosinusitis; Nasal; Polyposis; Eosinophilia; Recurrence
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