The Efficacy of phytoestrogens with Clomiphene Citrate for Ovulation Induction in Women with Polycystic Ovary Syndrome
Albasri, F., Sarhan, A., abdo, A., Abdelrhman, A. (2023). The Efficacy of phytoestrogens with Clomiphene Citrate for Ovulation Induction in Women with Polycystic Ovary Syndrome. EKB Journal Management System, 29(1.2), 142-148. doi: 10.21608/zumj.2020.37755.1910
Fatma Omar Albasri; Abdel-Mageed Mahmoud Sarhan; ahmed abdo; Amr Ahmed Abdelrhman. "The Efficacy of phytoestrogens with Clomiphene Citrate for Ovulation Induction in Women with Polycystic Ovary Syndrome". EKB Journal Management System, 29, 1.2, 2023, 142-148. doi: 10.21608/zumj.2020.37755.1910
Albasri, F., Sarhan, A., abdo, A., Abdelrhman, A. (2023). 'The Efficacy of phytoestrogens with Clomiphene Citrate for Ovulation Induction in Women with Polycystic Ovary Syndrome', EKB Journal Management System, 29(1.2), pp. 142-148. doi: 10.21608/zumj.2020.37755.1910
Albasri, F., Sarhan, A., abdo, A., Abdelrhman, A. The Efficacy of phytoestrogens with Clomiphene Citrate for Ovulation Induction in Women with Polycystic Ovary Syndrome. EKB Journal Management System, 2023; 29(1.2): 142-148. doi: 10.21608/zumj.2020.37755.1910

The Efficacy of phytoestrogens with Clomiphene Citrate for Ovulation Induction in Women with Polycystic Ovary Syndrome

Zagazig University Medical Journal
Article 569, Volume 29, Issue 1.2, January 2023, Page 142-148  XML PDF (279.54 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.37755.1910
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Authors
Fatma Omar Albasri email 1; Abdel-Mageed Mahmoud Sarhan2; ahmed abdo3; Amr Ahmed Abdelrhman4
1Resident of Obstetrics and Gynecology, Alkhoms Hospital, Misurata University, Libya
2Professor and Head of obstetrics and Gynaecology Faculty of Medicine - Zagazig University
3Assistant Professor of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University
4Lecturer of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University
Abstract
Background: Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in premenopausal women. This study aimed to evaluate the efficacy of isoflavonoids with clomiphene citrate during ovulation induction in PCOS women on the endometrial thickness which has an impact on pregnancy rate. Patients and methods: A prospective randomized clinical trial study was carried in Gynecology and Obstetrics Department, Zagazig University Hospitals on 160 infertile PCOS patients during the period from January 2019 to November 2019 to assess the effect of isoflavonoids in patients managed by clomiphene ovulation induction, triggered by HCG injection. All patients were divided into two groups: group I: included 80 women receiving Clomiphene citrate (CC) plus Isoflavonoids. Group 2: included 80 women receiving Clomiphene citrate only. Results: showed that the days till HCG injection were lower significantly in group I compared to group II which indicate better ovulation. As for the endometrial thickness, it was higher significantly in group I compared to group II. The number of ovulatory follicle(s) as single, two or three showed no statistical significant difference between the studied groups. The pregnancies number was higher significantly in group I where phytoestrogens were added to CC than group II. On the other hand, there was no statistical significant difference between the studied groups as regard the number of biochemical pregnancies between group I and group II. Conclusion: current results showed that Phytoestrogen (PE) (Isoflavonoids) with CC induced cycles, improved the endometrial thickness, promoted follicular maturation in a shorter time and also improved clinical pregnancy rates.
Keywords
Human chorionic gonadotropin; clomiphene Citrate; Isoflavonoids; polycystic ovary syndrome
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