Design and Synthesis of Peptide Derivatives Act as DNA Binding Agent and Discovery of Potent Carbonic Anhydrase Inhibitors Using Docking Studies
(2010). Design and Synthesis of Peptide Derivatives Act as DNA Binding Agent and Discovery of Potent Carbonic Anhydrase Inhibitors Using Docking Studies. EKB Journal Management System, 53(2), 279-299. doi: 10.21608/ejchem.2010.1221
. "Design and Synthesis of Peptide Derivatives Act as DNA Binding Agent and Discovery of Potent Carbonic Anhydrase Inhibitors Using Docking Studies". EKB Journal Management System, 53, 2, 2010, 279-299. doi: 10.21608/ejchem.2010.1221
(2010). 'Design and Synthesis of Peptide Derivatives Act as DNA Binding Agent and Discovery of Potent Carbonic Anhydrase Inhibitors Using Docking Studies', EKB Journal Management System, 53(2), pp. 279-299. doi: 10.21608/ejchem.2010.1221
Design and Synthesis of Peptide Derivatives Act as DNA Binding Agent and Discovery of Potent Carbonic Anhydrase Inhibitors Using Docking Studies. EKB Journal Management System, 2010; 53(2): 279-299. doi: 10.21608/ejchem.2010.1221

Design and Synthesis of Peptide Derivatives Act as DNA Binding Agent and Discovery of Potent Carbonic Anhydrase Inhibitors Using Docking Studies

Egyptian Journal of Chemistry
Article 7, Volume 53, Issue 2, April 2010, Page 279-299  XML PDF (1.3 MB)
DOI: 10.21608/ejchem.2010.1221
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Abstract
NEW peptide series of 2-(2-oxo-2H benzo[h] chromen-4-yl) acetyl ........derivatives 3-5, 15-20 and their corresponding methyl esters 6-14 were synthesized. Structures of the synthesized products were characterized by correct elemental analysis, IR, Mass and 1H-NMR spectroscopy. DNA binding activities were performed. Some synthesized compounds showed high binding affinity against DNA. Virtual screening using molecular docking studies of the synthesized compounds were performed, the molecular docking results indicate that, most of the synthesized compounds are more suitable inhibitors against carbonic anhydrase isozyme (CA) than reference drug.
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