Complement Levels and Risk of Organ Involvement in Patients with Systemic Lupus Erythematosus | ||||
SVU-International Journal of Medical Sciences | ||||
Article 9, Volume 2, Issue 2, July 2019, Page 50-56 PDF (275.65 K) | ||||
Document Type: Original research articles | ||||
DOI: 10.21608/svuijm.2019.122274 | ||||
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Authors | ||||
Esam M. Abu Al-Fadl1; Ahmed R. Radwan1; Abdallah E.M. Ali2; Abeer H. Masoud1 | ||||
1Rheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt | ||||
2Clinical Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt | ||||
Abstract | ||||
Objectives: to estimate the effect of complement level changes on clinical manifestations, visceral damage and mortality in our patients with SLE. Patients and method(s): A cross sectional study including 50 patients attending to South Valley University Hospitals have been included in the study for assessment of complement levels in patients with SLE and correlating complement levels with renal, neuropsychiatric, cardiac and hematological manifestations of SLE. Result(s): The most common organ system involved was the musculoskeletal system, with arthritis in 76% of the cases. This was followed by cutaneous manifestations (72%), then lupus nephritis (62%), CNS lupus (44%), hematological (30%) and lastly CVS (12%). Non of our cases showed liver impairment. Around two thirds of patients with renal involvement had consumed complement, compared to only 26% among those with no renal involvement; with a significant difference. It also shows that there is no significant difference between hypertension and complement level. Over 72% of patients with CNS involvement had consumed complement, compared to only 32% among those with no CNS involvement; with a significant difference. There is no significant relation between blood disorders, arthritis, mucocutaneous in lupus patients and complement consumption. Conclusion: Our study suggested that complement consumption was strongly associated with lupus nephritis and to a lesser extent; CNS lupus, but not with other organ involvement in SLE patients. | ||||
Keywords | ||||
SLE; Complement; Organ involvement | ||||
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