The Use of Close Relative Allo-Graft Intermingled with Auto-Graft for the Management of Extensive Burn Injury | ||||
The Egyptian Journal of Plastic and Reconstructive Surgery | ||||
Article 5, Volume 44, Issue 3, July 2020, Page 421-429 PDF (26.98 MB) | ||||
Document Type: Research article | ||||
DOI: 10.21608/ejprs.2020.122298 | ||||
View on SCiNiTO | ||||
Authors | ||||
Essam Morsi* 1; Ahmed Mostafa2; Omar Shouman2; Mohamed El Hadidi2; Shirene Abdel Ghani Abo Mazroa2 | ||||
1The Burn Center, Ahmed Maher Teaching Hospital | ||||
2Faculty of Medicine, Mansoura University | ||||
Abstract | ||||
Major burn injury management represents a difficult issue especially in developing countries. Skin auto-grafts is the best natural skin substitute for replacing burned skin but its rarity in major burns patients stand as an obstacle to be used. Early deep burn wounds excision and coverage of wounds more than 30% of body surface area is the main strategy for wound management in massive burns yet with the absence of skin banks (skin allo-grafts) and expensive artificial skin substitute's coverage of raw wounds by these methods is not applicable in Egypt. In this study, we try to evaluate the benefits to use both minimal sheets of auto-grafts covered by enough sheets of allo-grafts to cover all raw area after excision. Using fresh skin allo-grafts obtained from 1st degree relative of patients as natural skin substitute. The auto-grafts are meshed 1 to 6 and fixed directly on raw areas while allo-grafts are meshed 1 to 2 and cover both auto-grafts and raw areas, noting that allo-grafts considered as temporary skin. Follow-up the clinical changing of these grafts and histopathologically analysis. Out of the 30 patients 8 had died, 10 patients needed other operations while 12 had healed with no more procedures. | ||||
Keywords | ||||
Extensive burn; Skin grafting; Allograft; Autograft; Skin substitutes | ||||
References | ||||
1- Tompkins R.G.: Survival from burns in the new millennium: 70 years experience from a single institution. Ann. Surg., 261 (2): 263-8: 2015. 2- Chu D.H.: Overview of biology, development, and structure of skin. In K. Wolff, L.A. Goldsmith, S.I. Katz, B.A. Gilchrest, A.S., 241-242, 2008. 3- Daugherty M.D., Timothy H.F. M.D., Amanda Ross M.D. and Michael Neumeister M.D.: Surgical Excision of Burn Wounds Best Practices Using Evidence-Based Medicine. Clin. Plastic Surg., 33-38, 2017. 4- Saidi S.: Live Skin Allograft in The Treatment of Severe Burn. Annals of African Surgery, 13 (2): 77-80, 2016. 5- Sutithanthiran N.: Acute rejection of renal allografts: Mechanistic insights and therapeutic options Kidney International, 51: 1289-1304, 1997. 6- Converse J.M. and Duchet G.: Successful homologous skin grafting in a war burn using an identical twin as a donor. Plastic and Reconstructive Surgery, 3: 342, 1947. 7- Coenen J.M.H., Klasen H.J. and Sauer F.W.: Successful homografting in an elderly patient with extensive burns using his identical twin brother as skin donor. Burns, 16 (3): 225-226, 1990. Egypt, J. Plast. Reconstr. Surg., July 2020 429 8- Leodoro B., Chang A. and Cama J.K.: Live sibling skin allo-grafts for severe burns in a pediatric patient. Journal of Pediatric Surgery Case Reports, 2 (11): 498-500, 2014. 9- Alexander J.W., MacMiian B.W., Law E. and Kittur D.S.: Treatment of severe bums with widely meshed skin autograft and meshed skin allograft overlay. Journal of Trauma, 21: 433, 1981. 10- Calota D.R., Nitescu C., Florescu I.P., et al.: Surgical management of extensive burns treatment using allografts. J. Med. Life, 5 (4): 486-490, 2012. 11- Phipps and Clarke J.A.: The use of intermingled autograft and allograft skin in the treatment of major burns in children. Br. J. Plastic Surgery, 44 (8): 608-611, 1991. 12- El-Meanawy Amr Mahmoud, Tarek Fouad Keshk, Magdy Ahmed Lolouah and Medhat Samy Hassan: The reliability of use of combined homograft and autograft in management of major burns, 6 (5): 1446-1452, 2019. 13- Qaryoute S., Mirdad I. and Hamail A.A.: Usage of autograft and allograft skin in treatment of burns in children. Burns, 27: 599-602, 2001. 14- Chua A.W.C., Khoo Y.C., Truong T.T.H., Woo E., Tan B.K. and Chong S.J.: From skin allograft coverage to allograftmicrograft sandwich method, 44 (5): 1302-1307, 2018. 15- Ninnemann J.L., Fisher J.C. and Frank H.A.: Prolonged Survival of Human Skin Allografts Following Thermal Injury Transplantation, 25 (2): 69-72, 1979. 16- Coruh Atilla M.D., Zeynep Tosun M.D. and Umut Ozbebit M.D.: Close Relative Intermingled Skin Allograft and Autograft Use in the Treatment of Major Burns in Adults and Children Journal of Burn Care & Research, 26 (6): 471-477, 2005. | ||||
Statistics Article View: 243 PDF Download: 489 |
||||