Urinary Netrin-1 as an Early Marker for Diabetic Nephropathy | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 2, Volume 81, Issue 5, October 2020, Page 1924-1930 PDF (538.71 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2020.122713 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Ezzat M. Mohammed; Fawzy A. El-Messallamy; Ahmed M. Mazroue; Islam A. Elsayed; Amal A. Zidan | ||||
| Abstract | ||||
| Background: Netrin-1, a laminin-related secreted protein, is a proximal tubular injury urinary marker. It is released in the urine of both humans and mice and highly stimulated after acute and chronic renal diseases. Objective: The current study aimed to assess the value of urinary netrin-1 level as an early marker for diabetic nephropathy. Patients and Methods: A total of 60 diabetic patients and 20 healthy controls were enrolled in this case-control study. Diabetic patients were subdivided into normoalbuminuria, microalbuminuria, and macroalbuminuria. Urinary netrin-1 levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Results: Urinary netrin-1 excretion was significantly higher in the diabetic group (1418.3±733.6 pg/mg creatinine) compared to the control group (477.4±283.6 pg/mg creatinine) with the highest value in the macroalbuminuria group (1919.4±573.4 pg/mg creatinine) and the lowest value in normoalbuminuria group (833.7±595.3 pg/mg creatinine). ROC curve analysis showed that urinary netrin 1/creatinine at a cutoff point of >630.75 pg/mg with AUC of 0.899 had 83.3% sensitivity and 85% specificity for prediction of diabetic nephropathy (P<0.001). Conclusion: Our study is suggesting that urinary netrin-1 may be a useful biomarker for early detection of diabetic nephropathy | ||||
| Keywords | ||||
| Diabetic nephropathy; Netrin-1; Albuminuria | ||||
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