Synthesis and Conformational Analysis of Some Erythropoietin Mimetic Peptides Using Microwave Energy | ||||
| Egyptian Journal of Chemistry | ||||
| Article 8, Volume 53, Issue 3, June 2010, Page 435-448 PDF (648.83 K) | ||||
| DOI: 10.21608/ejchem.2010.1233 | ||||
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| Abstract | ||||
| THE CURRENT study describes the synthesis of Erythropoietin- ......which is a prohibited hormone by WADA-mimetic peptides [(AFIII54(chain I), (Ser)12AFIII54(chain II), AFIII54 with addition of Gly and Tyr in position 4 and 5, respectively (chain VI), AFIII54 devoid (Thr)9 and )Trp)10 (chain VII), (EMP3(chain III),(Ser)15EMP3 (chain IV), (Ala)15EMP3(chain V), EMP3 with addition of Gly and Tyr in position 7 and 8, respectively (chain VIII) and EMP3 devoid (Thr)12and (Trp)13(chain IX) ] by SPPS using microwave energy which accelerated reaction rate and improved the purities and yield. Conformational analysis using FT-IR spectroscopy showed that most the synthesised peptides existed in α-helix structure . Also, biological activity for one of these sequences was studied. | ||||
| Keywords | ||||
| erythropoietin; Mimetic peptides; Synthesis and Microwave conformational analysis | ||||
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