Studies on the Effect of Aqueous Green Tea Extract on Lipid Profile and Vascular Reactivity in Hypercholesterolemic Albino Rats | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 7, Volume 81, Issue 5, October 2020, Page 1958-1966 PDF (582.05 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2020.123477 | ||||
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| Authors | ||||
Mohammed Hassan El-Bakry; Ramadan Hassan Ibrahim; El-Shazly Abdelaal Mohaseb 
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| Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt | ||||
| Abstract | ||||
| Background: Hypercholesterolemia is one of the most important risk factors for atherosclerosis and subsequent cardiovascular disease (CVD). CVD is the leading cause of cardiovascular morbidity and mortality worldwide, currently, there is a major trend to use herbal remedies for the treatment and prevention of hypercholesterolemia. Objective: In the present work, we investigated the effect of aqueous green tea extract on lipid profile and vascular reactivity & changes in body weight in hypercholesterolemic albino rats Materials and methods: Adult male albino rats were chosen as an animal model for this study. Rats were brought from animal house, Faculty of Medicine, Assiut University, Assiut, Egypt, and were maintained on a balanced diet with water supply freely in clean containers. They were kept for two weeks to adapt to the laboratory conditions before the start of the experiment. Forty age-matched male albino rats with initial body weights ranging from 200 to 220g were used. Results: In group (III & IV), total cholesterol, LDL, and triglyceride levels were significantly decreased respectively& HDL were significantly increased compared with the group II (p < 0.05). also in group (III & IV) the aortic contractility is decreased and aortic relaxation were significantly increased compared with the group II (p < 0.05) & body weight was decreased significantly (p < 0.05) in group IV compared with the group II. Conclusion: The results obtained by the present study showed that administration of aqueous green tea extract to the hypercholsterolemic rats has a role in improvement of plasma lipids, vascular reactivity& body weight. | ||||
| Keywords | ||||
| Aqueous green tea; Lipid profile; Vascular reactivity; Hypercholesterolemic albino rats | ||||
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