Role of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in the diagnosis of Neonatal Hypoxic-Ischemic Injury
Mahmoud, B., Solyman, M., Ali, M., Zaki, K. (2021). Role of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in the diagnosis of Neonatal Hypoxic-Ischemic Injury. EKB Journal Management System, 25(1), 8-17. doi: 10.21608/smj.2020.41470.1190
Barakat Mohmed Mahmoud; Mohammad Tharwat Mahmoud Solyman; Mohammad Zaki Ali; Khaled Fawzy Zaki. "Role of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in the diagnosis of Neonatal Hypoxic-Ischemic Injury". EKB Journal Management System, 25, 1, 2021, 8-17. doi: 10.21608/smj.2020.41470.1190
Mahmoud, B., Solyman, M., Ali, M., Zaki, K. (2021). 'Role of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in the diagnosis of Neonatal Hypoxic-Ischemic Injury', EKB Journal Management System, 25(1), pp. 8-17. doi: 10.21608/smj.2020.41470.1190
Mahmoud, B., Solyman, M., Ali, M., Zaki, K. Role of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in the diagnosis of Neonatal Hypoxic-Ischemic Injury. EKB Journal Management System, 2021; 25(1): 8-17. doi: 10.21608/smj.2020.41470.1190

Role of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in the diagnosis of Neonatal Hypoxic-Ischemic Injury

Sohag Medical Journal
Article 2, Volume 25, Issue 1, January 2021, Page 8-17  XML PDF (733.75 K)
Document Type: Original Article
DOI: 10.21608/smj.2020.41470.1190
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Authors
Barakat Mohmed Mahmoud email 1; Mohammad Tharwat Mahmoud Solyman2; Mohammad Zaki Ali3; Khaled Fawzy Zaki4
1Radiology department Sohag faculty of medicine Sohag university
2Radiology Department,Sohag faculty of medicine, Sohag University
3Radiology Department , Sohag Faculty of medicine , Sohag University
4Radiology department ,Sohag faculty of medicine ,Sohag university
Abstract
Background: Hypoxic Ischemic Encephalopathy is defined as a heterogeneous, clinically defined syndrome characterized by disturbed neurologic function in the earliest days of life in a neonate. Proton MR spectroscopy could reveal brain ischemic injuries in asphyxiated neonates earlier than T1- or T2-weighted MR imaging. MR spectroscopy and MR imaging is very important for the diagnosis of hypoxic-ischemic injury.
Patients and Methods: A cross-sectional study. From December 2018 to December 2019, 50 full-term neonates were admitted to Neonatal Care Unit (NCU) in Sohag University Hospital with signs of HIE and referred to the Radio Diagnosis Department for brain imaging. MR imaging studies were performed using MRI system 1.5 tesla Achieva, Philips superconductive MRI system. Our MRI sequences 1. Axial T1WI. 2. Axial T2WI. 3. Axial FLAIR. 4. Axial DWI. 5. proton MR spectroscopy
Results: The study included 50 neonates; 7 of them had normal MRI findings. The other 43 neonates showed different patterns of injury; 24 neonates showed a central pattern of injury,11 neonates show peripheral patterns of injury, While the other 8 neonates had shown both central and peripheral patterns of brain injury. Only 45 of examined neonates shows abnormal lactate peak. The sensitivity of MRS is 100%. However, the specificity is low 70 %, the overall accuracy is 60 %.
Conclusion: MR spectroscopy is an accurate, sensitive and non-invasive method for early detection of perinatal ischemic brain injuries
Keywords
MRS; MRI; NHIE
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