DOES VITAMIN D CONCENTRATION IS CORRELATED TO CHRONIC HEPATITIS C TREATMENT FAILURE: A CASE CONTROL STUDY | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 11, Volume 51, Issue 1 - Serial Number 51, March 2015, Page 152-163 PDF (558.45 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2015.12501 | ||||
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| Author | ||||
| Ahmed Abdelsalam | ||||
| Misr International University, Department of Biochemistry, Faculty of Pharmacy | ||||
| Abstract | ||||
| Egypt has the highest prevalence rate of Hepatitis C virus (HCV) in the world, where, chronic hepatits C (CHC) is considered a major health problem. The standard treatment of CHC is combination therapy of pegylated interferon and ribavirin. Successful treatment and sustained virological response (SVR) are only achieved in 30% of patients. Major adverse effects and high cost of the treatment makes predicting the treatment output is an important approach. The aim of this study to find an association between Vitamin D concentration with achieving SVR. Patients and methods: In this study; 250 patients were selected and divided into 3 groups (100 CHC patients who achieved SVR, 100 CHC patients who did not achieve SVR, and 50 patients as control). Blood samples were collected to measure vitamin D concentration and routine liver function tests. Results: Vitamin D concentration was found significantly higher in the responders more than non responders. Conclusion: Vitamin D concentration is valid predector to the response of CHC patients to combination of pegylated interferon and ribvirin thrapy | ||||
| Keywords | ||||
| HCV genotype 4; Interferon and ribavirin therapy; vitamin D concentration | ||||
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