Evalution of hormonal metabolic and cardiorespiratory effects of medetomidine in one humped camels / | ||||
| Mansoura Veterinary Medical Journal | ||||
| Article 8, Volume 8, Issue 1, June 2006, Page 99-110 PDF (538.54 K) | ||||
| Document Type: Original Articles | ||||
| DOI: 10.21608/mvmj.2006.125023 | ||||
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| Abstract | ||||
| his study was aimed to evaluate file effects of alpha 2-adrenoceptor agonist medetomidine on sorne hormonal, metalJolic and cardiorespiratory responses in healthu one humped camels . Five apparently healthy male camels ageing 3-4 years . weighing 220- 280 kg were used . Tfte experiment was designed to invesligale lite physiological effects of different intravenous doses of medetomidine ( 20, 30 and 40 pg IKg ) . All animals were treated with each dose with an interval of orie week and each animal served as control ( zero line J before inject ion . PhLJsiologicalfindings heart rate, respira tory rate. rectal body temperature and electrocardiogram were monitored pre- and post iryection of medetomidine after 5, 30,60 and 120 min . Complete hematological chang es were measured pre- and post-injection . Both blood glucose and insulin level were estimated . Cortisol was measured bu single antibody radioimmunoassau ( RIA J tech- 1tique . Medelomidi1te suppressed insulin secretion a1td induces inilinl lt!J1JOgl!Jcc111in fallowed by increased blood glucose levels . The hyperglycemic effects of medelomidine was not dose- dependent . There was non significant changes in hematological events. Plasma cortisol levels were sltowed non significant increases willtln dose 20 11g/ leg body weight while there was significant increases with dose 30 and 40 Jig / leg.• Body temperature was moderatelu decreased . Tlte heart rate was showed a bradycardia with irregular rhythm, and decreases the conduction in the conductive system of the heart.affected T waves. The respiratory rate was affected will t an initial slowing for few seconds to 1-2 min. post-injection. and increasing to normal within 120 min.It could be concluded that healthy camels can usually compensate for these physio logical changes during sedation and analgesia; however medetomidine are contraindi cated in cardiovascular and respiratory diseased camels. Moreover. animal ECG must be applied before pre anaethetic medication or anesthesia in order to prevent the sud den death of lite animals during anesthesia spedally in large animals as camels. | ||||
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