SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW 1,2,4-TRIAZINO[6,1-B]QUINAZOLINE DERIVATIVES.
El-Enany, M. (2015). SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW 1,2,4-TRIAZINO[6,1-B]QUINAZOLINE DERIVATIVES.. EKB Journal Management System, 51(1), 164-175. doi: 10.21608/ajps.2015.12504
Mervat El-Enany. "SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW 1,2,4-TRIAZINO[6,1-B]QUINAZOLINE DERIVATIVES.". EKB Journal Management System, 51, 1, 2015, 164-175. doi: 10.21608/ajps.2015.12504
El-Enany, M. (2015). 'SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW 1,2,4-TRIAZINO[6,1-B]QUINAZOLINE DERIVATIVES.', EKB Journal Management System, 51(1), pp. 164-175. doi: 10.21608/ajps.2015.12504
El-Enany, M. SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW 1,2,4-TRIAZINO[6,1-B]QUINAZOLINE DERIVATIVES.. EKB Journal Management System, 2015; 51(1): 164-175. doi: 10.21608/ajps.2015.12504

SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW 1,2,4-TRIAZINO[6,1-B]QUINAZOLINE DERIVATIVES.

Al-Azhar Journal of Pharmaceutical Sciences
Article 12, Volume 51, Issue 1 - Serial Number 51, March 2015, Page 164-175  XML PDF (470.61 K)
Document Type: Original Article
DOI: 10.21608/ajps.2015.12504
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Author
Mervat El-Enany
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Abstract
In this study, novel 3-substituted 1,2,4-triazino[6,1-b]quinazolines 4a-e, 8-substituted-1H-[1,2,4]triazino[6,1-b]quinazoline-2,4,10(3H)-triones 8a&b  and 2-substituted 1,2,4-triazino[6,1-b]quinazolines 9a-d, 10 & 11 were synthesized from 3-amino-6-bromo-2-ethoxycarbonylquinazolin-4(3H)-one (2b) and3-amino-2-aminocarbonylquinazolin-4(3H)-one 7a&b. Some of the newly synthesized compounds were tested for their antimicrobial activity and analgesic activity.
Depending on the obtained results, the newly synthesized compounds possess significant analgesic activity and mild antimicrobial activity.
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