Significance of CXC chemokine receptor 4 (CXCR4) in Renal Cell Carcinoma
El Balshy, A., Abd El Maksoud, A., El Sawi, R., Nagieb, Y. (2021). Significance of CXC chemokine receptor 4 (CXCR4) in Renal Cell Carcinoma. EKB Journal Management System, 38(Academic issue), 73-91. doi: 10.21608/bmfj.2020.125160
Abd Ellatif El Balshy; Ahlam Abd El Maksoud; Rasha El Sawi; Yara Nagieb. "Significance of CXC chemokine receptor 4 (CXCR4) in Renal Cell Carcinoma". EKB Journal Management System, 38, Academic issue, 2021, 73-91. doi: 10.21608/bmfj.2020.125160
El Balshy, A., Abd El Maksoud, A., El Sawi, R., Nagieb, Y. (2021). 'Significance of CXC chemokine receptor 4 (CXCR4) in Renal Cell Carcinoma', EKB Journal Management System, 38(Academic issue), pp. 73-91. doi: 10.21608/bmfj.2020.125160
El Balshy, A., Abd El Maksoud, A., El Sawi, R., Nagieb, Y. Significance of CXC chemokine receptor 4 (CXCR4) in Renal Cell Carcinoma. EKB Journal Management System, 2021; 38(Academic issue): 73-91. doi: 10.21608/bmfj.2020.125160

Significance of CXC chemokine receptor 4 (CXCR4) in Renal Cell Carcinoma

Benha Medical Journal
Article 6, Volume 38, Academic issue, February 2021, Page 73-91  XML PDF (1.19 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.125160
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Authors
Abd Ellatif El Balshy1; Ahlam Abd El Maksoud2; Rasha El Sawi1; Yara Nagieb3
1Department of pathology, Benha faculty of medicine, Benha University, Egypt
2Department of Pathology, Benha faculty of medicine, Benha University, Egypt
3Benha Fever Hospital, Benha, Egypt
Abstract
Background: Cancer stem cells (CSCs) represent a population with tumour initiating, self-renewal, and differentiation potential. The aim of the work is to evaluate the expression patterns and clinical significance of chemokine receptor type 4 (CXCR4) as a novel CSC marker in renal cell carcinoma (RCC). Material and Methods: the expression of CXCR4 was examined in 50 well-defined renal tumour tissues, including 28 clear cell renal cell carcinomas (ccRCCs), 11 papillary renal cell carcinomas (pRCCs), and 11 chromophobe renal cell carcinomas (ChRCCs) with immunohistochemistry staining, the association between expression of this marker and clinicopathologic parameters, was then analyzed.  Results: CXCR4 expression & intensity was significantly correlated with RCC clinicopathological features as grade, stage, size of the tumor and microvascular invasion (MVI) but there was insignificant correlation between histopathological types and the pattern of CXCR4 expression and its intensity . Conclusion: increased CXCR4 expression was associated with more aggressive tumour behaviour in RCC patients, especially in pRCC and ccRCC subtypes due to their more metastatic behaviour. These findings suggest that CXCR4 can be considered as a novel prognostic and therapeutic marker for targeted therapy of renal carcinoma.
 
Keywords
Cancer stem cells; Renal cell carcinoma; chemokine receptor type 4
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