Correlation between Vascular Endothelial Cell Growth Factor (VEGF) and Muscular Ultrasonography Finding in Knee Osteoarthritis
Khalil, M., Serag Eldeen, M., E. Egela, S., Hadhoud, Y., Al Tabbakh, A. (2021). Correlation between Vascular Endothelial Cell Growth Factor (VEGF) and Muscular Ultrasonography Finding in Knee Osteoarthritis. EKB Journal Management System, 38(1), 102-112. doi: 10.21608/bmfj.2020.125170
Mayada Khalil; Mounir Serag Eldeen; Samy E. Egela; Yasmine Hadhoud; Al-Shaimaa Al Tabbakh. "Correlation between Vascular Endothelial Cell Growth Factor (VEGF) and Muscular Ultrasonography Finding in Knee Osteoarthritis". EKB Journal Management System, 38, 1, 2021, 102-112. doi: 10.21608/bmfj.2020.125170
Khalil, M., Serag Eldeen, M., E. Egela, S., Hadhoud, Y., Al Tabbakh, A. (2021). 'Correlation between Vascular Endothelial Cell Growth Factor (VEGF) and Muscular Ultrasonography Finding in Knee Osteoarthritis', EKB Journal Management System, 38(1), pp. 102-112. doi: 10.21608/bmfj.2020.125170
Khalil, M., Serag Eldeen, M., E. Egela, S., Hadhoud, Y., Al Tabbakh, A. Correlation between Vascular Endothelial Cell Growth Factor (VEGF) and Muscular Ultrasonography Finding in Knee Osteoarthritis. EKB Journal Management System, 2021; 38(1): 102-112. doi: 10.21608/bmfj.2020.125170

Correlation between Vascular Endothelial Cell Growth Factor (VEGF) and Muscular Ultrasonography Finding in Knee Osteoarthritis

Benha Medical Journal
Article 9, Volume 38, Issue 1, April 2021, Page 102-112  XML PDF (768.74 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.125170
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Authors
Mayada Khalil1; Mounir Serag Eldeen1; Samy E. Egela1; Yasmine Hadhoud1; Al-Shaimaa Al Tabbakh2
1Department of Rheumatology , Rehabilitation and physical medicine, Benha faculty of medicine , Benha University, Egypt.
2Department of Medical Microbiology and Immunology department, Benha Faculty of medicine, Benha University, Egypt.
Abstract
Background: Osteoarthritis (OA) is a degenerative joint disorder affecting articular cartilage that may be associated with synovial inflammation. The vascular endothelial growth factor is implicated in the pathogenesis of OA. This study aimed to assess man serum vascular endothelial growth factor (VEGF) levels in patients with primary knee osteoarthritis (KOA) and to evaluate their correlation with clinical manifestations, physical function and musculoskeletal-ultrasonography findings. Results: This is a case control study conducted on 50 subjects, thirty patients with primary Knee OA recruited from the outpatients’ clinic of the Rheumatology, Rehabilitation and Physical Medicine Department Benha University Hospitals, from November 2018 to November 2019. Twenty age and sex matched apparently healthy adult individuals were also included as a control group. The present study showed a highly statically significant difference (p < 0.0001) between the mean serum levels of VEGF in the patients’ and the control groups being higher in the patients group compared to the control group (<0.001). The current study revealed a strong significant positive correlations of VEGF levels with the presence of Baker’s cysts, cartilage thickness index and color Doppler US grading (p < 0.0001). Significant positive correlations were also reported between VEGA levels (p=<0.001) and WOMAC total and WOMAC sub scores.
Conclusions: VEGF serum levels are highly correlated with clinical, functional and musculoskeletal ultrasound severity of KOA. Thus it could be used as a potential biomarker for estimating Knee OA disease status
Keywords
Knee OA; WOMAC; VEGF; Musculoskeletal Ultrasound
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