DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,4-DIAMINO PYRIMIDOTHIAZINE DERIVATIVES | ||||
Al-Azhar Journal of Pharmaceutical Sciences | ||||
Article 5, Volume 52, Issue 2 - Serial Number 52, September 2015, Page 82-100 PDF (946.9 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ajps.2015.12534 | ||||
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Author | ||||
Helmy Sakr | ||||
Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt | ||||
Abstract | ||||
The thermal condensation of 2,4-diamino 5-bromo-6-hydroxypyrimidine with 2-amino-3-mercaptopropylaniline derivatives (6) and 2-amino-3-mercaptopropymethyllaniline derivatives (9) resulted in 2,4-diamino-6-substituted anilinomethlyl 6,7-dihydro-8H-pyrimido[4,5-b][1,4] thiazine derivatives (13, R= H) and 2,4-diamino-6-substituted methylanilinomethlyl 6,7-dihydro-8-methyl-pyrimido[4,5-b][1,4] thiazine derivatives (13, R= CH3) respectively. The synthesized compounds were screened for antimicrobial activity and it was found that the screened compounds have antimicrobial and antifungal activity comparable to chloramphenicol and terbinafine. | ||||
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