Synthesis , Reactions and Antimicrobial Activity on Some Novel Phthalazinone Derivatives
(2010). Synthesis , Reactions and Antimicrobial Activity on Some Novel Phthalazinone Derivatives. EKB Journal Management System, 53(5), 645-660. doi: 10.21608/ejchem.2010.1255
. "Synthesis , Reactions and Antimicrobial Activity on Some Novel Phthalazinone Derivatives". EKB Journal Management System, 53, 5, 2010, 645-660. doi: 10.21608/ejchem.2010.1255
(2010). 'Synthesis , Reactions and Antimicrobial Activity on Some Novel Phthalazinone Derivatives', EKB Journal Management System, 53(5), pp. 645-660. doi: 10.21608/ejchem.2010.1255
Synthesis , Reactions and Antimicrobial Activity on Some Novel Phthalazinone Derivatives. EKB Journal Management System, 2010; 53(5): 645-660. doi: 10.21608/ejchem.2010.1255

Synthesis , Reactions and Antimicrobial Activity on Some Novel Phthalazinone Derivatives

Egyptian Journal of Chemistry
Article 3, Volume 53, Issue 5, October 2010, Page 645-660  XML PDF (426.05 K)
DOI: 10.21608/ejchem.2010.1255
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Abstract
 
ASIMPLE and efficient synthesis of [4-(3, 4-dimethylphenyl)-5, 6, 7, 8-tetrabromo-1-oxo-1H-phthalazin-2-yl]-acetic acid hydrazide (IV) has been carried out. The obtained hydrazide (IV) has been used in synthesis of some interesting heterocycles such as pyrazolone, thiazolidinone, pyrimidine, benzoxazine lactam, rhodanine, quinazoline and benzoxazinone (VIII
 
–XVII). Some of the prepared compounds tested for in vitro antibacterial activities. Among those tested, many compounds showed good antibacterial activities.
Keywords
Phthalazinone; pyrazolone; thiazolidinone; Azitidinone; Quinazoline; Pyrimidine derivatives and Antimicrobial activity
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