Synthesis , Reactions and Antimicrobial Activity on Some Novel Phthalazinone Derivatives | ||||
Egyptian Journal of Chemistry | ||||
Article 3, Volume 53, Issue 5, October 2010, Page 645-660 PDF (426.05 K) | ||||
DOI: 10.21608/ejchem.2010.1255 | ||||
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Abstract | ||||
ASIMPLE and efficient synthesis of [4-(3, 4-dimethylphenyl)-5, 6, 7, 8-tetrabromo-1-oxo-1H-phthalazin-2-yl]-acetic acid hydrazide (IV) has been carried out. The obtained hydrazide (IV) has been used in synthesis of some interesting heterocycles such as pyrazolone, thiazolidinone, pyrimidine, benzoxazine lactam, rhodanine, quinazoline and benzoxazinone (VIII –XVII). Some of the prepared compounds tested for in vitro antibacterial activities. Among those tested, many compounds showed good antibacterial activities. | ||||
Keywords | ||||
Phthalazinone; pyrazolone; thiazolidinone; Azitidinone; Quinazoline; Pyrimidine derivatives and Antimicrobial activity | ||||
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