Gene polymorphisms and risk of preeclampsia in Egyptian women | ||||
| Evidence Based Women's Health Journal | ||||
| Article 3, Volume 10, Issue 4, November 2020, Page 273-283 PDF (1.22 MB) | ||||
| Document Type: Original Article | ||||
| DOI: :10.21608/ebwhj.2019.19794.1056 | ||||
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| Authors | ||||
Mohamed Abdel-moniem Ibrahem   1; Magdy M. Ibrahim2; Amira S. Al-Karamany3; Rasha L. Etewa4
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| 1Department of Obstetrics and Gynecology, Faculty of medicine, Zagazig University, Zagazig, Egypt. | ||||
| 2Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Egypt, | ||||
| 3Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Egypt | ||||
| 4Department of Pathology/Medical Biochemistry, College of Medicine, Jouf University, Sakaka, Saudi Arabia | ||||
| Abstract | ||||
| Aim: The aim of this study was to evaluate the possible association between ACE I/D, AT1 receptor 1166 A:C, AT2 receptor-1332 A:G, and MMP-9-1562 C:T polymorphisms and risk of preeclampsia in Egyptian women. Materials and Methods: This case-control study included 108 pregnant women was allocated into two groups, 54 pre-eclamptic women group and control group which included 54 normotensive pregnant women. Genotyping of AT1 1166 A:C and AT2 −1332 A: G were performed by duplex polymerase chain reaction-restriction fragment length polymorphism PCR-RFLP. Genotyping of I/D polymorphism of ACE was carried out by PCR and genotyping of MMP-9 −1562C/T was performed by tetra-primer amplification refractory mutation system T- ARMS–PCR. Results: The DD genotype of ACE gene was significantly associated with increased risk of preeclampsia [OR (95% CI) = 2.47 (0.72–8.5), p = 0.02] and the D allele was significantly associated with an increased risk of preeclampsia [OR (95% CI) = 1.95 (1.08–3.54), p = 0.02]. The AT2 GG genotype frequency was significantly higher in preeclampsia [OR (95% CI) = 3.24 (1.25–8.41), p = 0.002] and the G allele [OR (95% CI) = 2.41 (1.39–4.18), p = 0.002]. However, the AT1 CC and MMP9 TT genotypes frequency were insignificantly associated with preeclampsia. Conclusion: ACE gene I/D and -1332A/G of AT2 receptor polymorphisms, but not AT1 receptor gene A1166C and MMP-9 (-1562 C/T) polymorphisms, could be related to the risk of preeclampsia in Egyptian women. | ||||
| Keywords | ||||
| Angiotensin converting enzyme; angiotensin II type 1-2 receptors; matrix metalloproteinase 9; preeclampsia | ||||
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