Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate
(2010). Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate. EKB Journal Management System, 53(6), 777-790. doi: 10.21608/ejchem.2010.1263
. "Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate". EKB Journal Management System, 53, 6, 2010, 777-790. doi: 10.21608/ejchem.2010.1263
(2010). 'Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate', EKB Journal Management System, 53(6), pp. 777-790. doi: 10.21608/ejchem.2010.1263
Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate. EKB Journal Management System, 2010; 53(6): 777-790. doi: 10.21608/ejchem.2010.1263

Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate

Egyptian Journal of Chemistry
Article 1, Volume 53, Issue 6, December 2010, Page 777-790  XML PDF (386.58 K)
DOI: 10.21608/ejchem.2010.1263
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Abstract
 
ALL living cell need tetrahydrofolate cofactor for the synthesis of ........ purines, some amino acid and thymidine. Most bacteria and plant produce this folate cofactor by de novo biosynthesis. Compounds that interfere with this pathway, antifolate agents have found use as anticancer. Thus, the 2-propyl-4H-3,1-benzoxazin-4-one (2) was synthesized and allowed to interaction with Ammonium acetate or formamide afforded -2- propylquinazolin-4(3H)-one (3). Behaviour of quinazolinone towards carbon electrophiles namely, aromatic aldehyde, chloroacetylchloride, and ethylchloroacetate has been investigated and all the synthesized compounds were tested as anti-cancer in National Cancer Institute (NCI) in USA.
Keywords
Benzoxazin-4-one; Quinazolin-4(3H) one and Anthranil
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