A Study to Evaluate KM/Propofol versus KM Alone for Procedural Sedation in Children | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 6, Volume 69, Issue 8, October 2017, Page 2981-2985 PDF (285.52 K) | ||||
Document Type: Original Article | ||||
DOI: 10.12816/0042839 | ||||
View on SCiNiTO | ||||
Authors | ||||
Abdulrahman Fayez Kinsara1; Ahmad Abdulaziz M. Almehmadi2; Turki Jafar Abdulmajid3; Motaz Ashoor4; Qusai Abdullah Al Saqabi5; Rakan Abdulrahman Alrzoq6; Badr Wadee S Abulhamail7; Randa Fahad Almatrafi8; Basim Salman w Almazrui9; Basem Abdullah Alghamdi10; Fawaz Sulaiman Ayed Alshammari11 | ||||
1King Faisal Hospital Makkah | ||||
2Ibn Sina National College | ||||
3Al Immam Abdulrahman Al Faisal Hospital | ||||
4King Abdulalziz General Hospital Jeddah Radiology Department | ||||
5Al Jouf University | ||||
6Imam University | ||||
7King Abdulaziz University Hospital | ||||
8Al-Noor Specialty Hospital | ||||
9GP in Aseer Hospital | ||||
10GP - Najran University Hospital | ||||
11University of Hail | ||||
Abstract | ||||
Background: The co-administration of ketamine and propofol (CoKP) is thought to maximize the beneficial profile of each medication, while minimizing the respective adverse effects of each medication. Objective: Our objective was to compare adverse events between ketamine monotherapy (KM) and CoKP for procedural sedation and analgesia (PSA) in a pediatric emergency department (ED). Methods: This was a prospective, randomized, single-blinded, controlled trial of KM vs. CoKP in patients between 3 and 21 years of age. The attending physician administered either ketamine 1 mg/kg i.v. or ketamine 0.5 mg/kg and propofol 0.5 mg/kg i.v. The physician could administer up to three additional doses of ketamine (0.5 mg/kg/dose) or ketamine/propofol (0.25 mg/kg/dose of each). Adverse events (e.g., respiratory events, cardiovascular events, unpleasant emergence reactions) were recorded. Secondary outcomes included efficacy, recovery time, and satisfaction scores. Results: Thirty-two patients were randomized to KM and 29 patients were randomized to CoKP. There was no difference in adverse events or type of adverse event, except nausea was more common in the KM group. Efficacy of PSA was higher in the KM group (99%) compared to the CoKP group (90%). Median recovery time was the same. Conclusions: We found no significant differences in adverse events between the KM and CoKP groups. While CoKP is a reasonable choice for pediatric PSA, our study did not demonstrate an advantage of this combination over KM. | ||||
Keywords | ||||
Ketamine; propofol; Procedural Sedation | ||||
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