Antioxidant and Antimicrobial Activities of Some Novel 2-Thiohydantoin Derivatives

Mutlaq, Dakhil Zughayir; Al-Shawi, Ali A. A.; AbdulJabar, Layla Adnan

doi:10.21608/ejchem.2020.47419.2963

	Antioxidant and Antimicrobial Activities of Some Novel 2-Thiohydantoin Derivatives
Egyptian Journal of Chemistry
Article 21, Volume 64, Issue 3, March 2021, Page 1315-1321 PDF (484.63 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.47419.2963
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Authors
Dakhil Zughayir Mutlaq ¹; Ali A. A. Al-Shawi ²; Layla Adnan AbdulJabar ³
¹Department of Chemistry, College of Education for Pure Sciences, University of Basrah , Basrah, Iraq
²Chemistry Department University of Basrah College of Education for Pure Sciences
³Department of Physiology, Medicines and Biochemistry, College of Veterinary Medicine, University of Basrah, Basrah, Iraq
Abstract
Four new 2-thiohydantoin derivatives (4a-d) were synthesized from the reaction of maleimide derivatives (3a-d) with phenylisothiocyanate. The structures of synthetic compounds were characterized using Fourier-transform infrared spectroscopy (FT-IR), 1H- and 13C-nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry. The antioxidant activity of the synthesized compounds showed inactive 4b and 4c compounds, moderately active 4a, and strongly active 4d, compared with vitamin C as positive control (IC50 values = 1.380, 1.726, 4.147, 8.085, and 9.826 µM, respectively). Antibacterial and antifungal activities of compounds showed that only compound 4b had an effect on Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger species.
Keywords
Bioactive heterocyclic compounds; 2-thiohydantoin; Antioxidant; Antibacterial; Antifungal


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