PRELIMINARY PHYTOCHEMICAL INVESTIGATION AND IN-VITRO ANTIDIABETIC ACTIVITY OF AN AYURVEDIC FORMULATION | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 2, Volume 43, Issue 2, December 2020, Page 135-139 PDF (419.34 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2020.127400 | ||||
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| Authors | ||||
| S. Gayatri1; V. Angel Seslin Monica2 | ||||
| 1Assistant Professor, Sri Ramachandra Faculty of Pharmacy, SRIHER (DU), Porur, Chennai-600116, Tamil Nadu, India | ||||
| 2Student, Sri Ramachandra Faculty of Pharmacy, SRIHER (DU), Porur, Chennai-600116, Tamil Nadu, India | ||||
| Abstract | ||||
| Objective: To carry out the preliminary phytochemical analysis and to perform the in-vitro anti diabetic activity for the ayurvedic poly herbal formulation. Material and Methods: Preliminary phytochemical analysis was performed as per the standard procedures. In-vitro anti-diabetic activity was done by two methods namely alpha amylase inhibitory assay and alpha glucosidase inhibitory assay by taking acarbose as a standard drug for the ayurvedic formulation. Statistical analysis is carried out by means of graphpad prism software version 6. Results and conclusion: Preliminary phytochemical analysis showed the presence of alkaloids, glycosides, phytosterols, phenols, flavonoids and terpenoids in the formulation. The poly herbal tablet produced 32.2% inhibition of alpha amylase activity at a concentration of 125 µg/ml and 80.8% inhibition of alpha glucosidase activity at a concentration of 62.5 µg/ml. The present study shows that the selected ayurvedic poly herbal tablets has an anti-diabetic activity comparable with that of allopathic drug - acarbose tablet. | ||||
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