Circulating Maternal Serum Cell Free Fetal DNA Levels for prediction of Preeclampsia
Soroura, M., El Shorbagy, M., SHAWKY, M., Borg, T., Wahba, K., Reyad, A. (2022). Circulating Maternal Serum Cell Free Fetal DNA Levels for prediction of Preeclampsia. EKB Journal Management System, 12(1), 77-85. doi: 10.21608/ebwhj.2020.28158.1093
Mohammad Soroura; Maged El Shorbagy; mohamed SHAWKY; TAMER Borg; Karim Wahba; Ahmed Reyad. "Circulating Maternal Serum Cell Free Fetal DNA Levels for prediction of Preeclampsia". EKB Journal Management System, 12, 1, 2022, 77-85. doi: 10.21608/ebwhj.2020.28158.1093
Soroura, M., El Shorbagy, M., SHAWKY, M., Borg, T., Wahba, K., Reyad, A. (2022). 'Circulating Maternal Serum Cell Free Fetal DNA Levels for prediction of Preeclampsia', EKB Journal Management System, 12(1), pp. 77-85. doi: 10.21608/ebwhj.2020.28158.1093
Soroura, M., El Shorbagy, M., SHAWKY, M., Borg, T., Wahba, K., Reyad, A. Circulating Maternal Serum Cell Free Fetal DNA Levels for prediction of Preeclampsia. EKB Journal Management System, 2022; 12(1): 77-85. doi: 10.21608/ebwhj.2020.28158.1093

Circulating Maternal Serum Cell Free Fetal DNA Levels for prediction of Preeclampsia

Evidence Based Women's Health Journal
Article 10, Volume 12, Issue 1, February 2022, Page 77-85  XML PDF (1.48 MB)
Document Type: Original Article
DOI: 10.21608/ebwhj.2020.28158.1093
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Authors
Mohammad Soroura email 1; Maged El Shorbagy2; mohamed SHAWKY2; TAMER Borg2; Karim Wahba2; Ahmed Reyad2
1Obstetrics and gynecology faculty of medicine Ain shams university
2Department of Obstetrics and Gynecology Faculty of Medicine – Ain Shams University
Abstract
Background: Pre-eclampsia is a pregnancy-specific disorder that has a worldwide prevalence of 5-15%. It is one of the main causes of maternal and perinatal morbidity and mortality globally and accounts for 50000–60000 deaths annually, with a predominance in the low- and middle-income countries. There is a great need to have a test for predication of women at high risk of developing preeclampsia.
Aim:This work aimed to assess the accuracy of maternal serum Cff-DNA concentration levels in primigravidas 10-20 weeks gestation as a predictive test for the development of preeclampsia.
Materials and Methods: A nested case-control study was conducted on 26 patients with PE and 26 matched controls rimigravidas in 10-20 weeks gestation recruited from Ain-Shams University Maternity Hospital. Laboratory work was done in Ali Khalifa laboratory of the biochemistry department, Faculty of Medicine, Ain-Shams University.
Results: The study showed a statistically significant increase median of severe preeclampsia compared to non-severe preeclampsia and control group according to cff-DNA (GE/ml). Also the study results revealed a statistically significant increase median of preeclampsia group compared to control group according to BMI, GA (wks), SBP and DBP,
Conclusion: Cff-DNA quantification can be considered as a promising marker for preeclampsia prediction, especially for the development of early-onset or severe preeclampsia.
Keywords
Cff-DNA; Preeclampsia; primigravida
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