Correlation Between Umblical Artery Doppler Indices With Neonatal Cord Blood Ischemic Modified Albumin in Diagnosis of Neonatal Asphyxia in High Risk Pregnancy
Elsayed, A., IBRAHIM, A., Elkafrawy, M., AbdRabou, I. (2022). Correlation Between Umblical Artery Doppler Indices With Neonatal Cord Blood Ischemic Modified Albumin in Diagnosis of Neonatal Asphyxia in High Risk Pregnancy. EKB Journal Management System, 12(1), 69-76. doi: 10.21608/ebwhj.2020.28154.1092
Alshaimaa Elsayed; ASMAA IBRAHIM; Mona Elkafrawy; IMAN AbdRabou. "Correlation Between Umblical Artery Doppler Indices With Neonatal Cord Blood Ischemic Modified Albumin in Diagnosis of Neonatal Asphyxia in High Risk Pregnancy". EKB Journal Management System, 12, 1, 2022, 69-76. doi: 10.21608/ebwhj.2020.28154.1092
Elsayed, A., IBRAHIM, A., Elkafrawy, M., AbdRabou, I. (2022). 'Correlation Between Umblical Artery Doppler Indices With Neonatal Cord Blood Ischemic Modified Albumin in Diagnosis of Neonatal Asphyxia in High Risk Pregnancy', EKB Journal Management System, 12(1), pp. 69-76. doi: 10.21608/ebwhj.2020.28154.1092
Elsayed, A., IBRAHIM, A., Elkafrawy, M., AbdRabou, I. Correlation Between Umblical Artery Doppler Indices With Neonatal Cord Blood Ischemic Modified Albumin in Diagnosis of Neonatal Asphyxia in High Risk Pregnancy. EKB Journal Management System, 2022; 12(1): 69-76. doi: 10.21608/ebwhj.2020.28154.1092

Correlation Between Umblical Artery Doppler Indices With Neonatal Cord Blood Ischemic Modified Albumin in Diagnosis of Neonatal Asphyxia in High Risk Pregnancy

Evidence Based Women's Health Journal
Article 9, Volume 12, Issue 1, February 2022, Page 69-76  XML PDF (577.42 K)
Document Type: Original Article
DOI: 10.21608/ebwhj.2020.28154.1092
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Authors
Alshaimaa Elsayed email 1; ASMAA IBRAHIM2; Mona Elkafrawy3; IMAN AbdRabou4
1Obstetrics and gynecology faculty of medicine for girls , Al-Azhar university
2Department of pediatric and neonate Faculty of Medicine For Girls Al-Azhar University..
3obeststric and gynecology Faculty of Medicine for Girls Al-AzharUniversity
4Obstetrics and Gynecology Faculty of Medicine for Girls Al-Azhar University
Abstract
Background: Neonatal asphyxia is a significant cause of neonatall morbidity and mortality worldwide.
Aim: This study aims to is to evaluate the significance of the cord blood ischemia-modified albumin (IMA) level as a diagnostic marker for neonatal asphyxia and to determine the associations of IMA levels with doppler findings in diagnosis of neonatal asphyxia in high risk pregnancy.
Materials and Methods: This is a prospective case control study that will be performed at obstetrics and gynecology department at Al-zahraa University Hospital. The study was carried out on 90 pregnant women who are attend the obstetrics department for labour and divided into two groups: Group A:(control group)it was include 30 healthy pregnant women. Group B:(study group) it was include 60 pregnant women with high risk pregnancy. Doppler measurements were obtained from umbilical and middle cerebral arteries,C/P ratio.IMA was measured by ELISA kits and expressed as picomole per milliliter.
Results: Ischemia-modified albumin levels were significantly higher in neonates of complicated pregnancies as compared to uncomplicated pregnancies (P<0.001). They were higher in newborns with neonatal asphyxia as compared to healthy controls (P=0.004).The C/P ratio-pulsatility index (PI) showed a significant difference between normal and complicated pregnancies with neonatal asphyxia (P<0.0001). IMA levels were significantly increased in cases with abnormal C/P ratio-PI.
Conclusion: Cord blood IMA levels may be accepted as a useful marker in diagnosis of neonatal asphyxia in high risk pregnancy. Abnormal umblical artery Doppler examinations are associated with elevated IMA levels in high risk pregnancy.
Keywords
UMBILICAL CORD DOPPLER AND ASPHEXIA
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