QUANTITATIVE ASSESSMENT OF TUMOR ASSOCIATED TISSUE EOSINOPHILIA IN ORAL SQUAMOUS CELL CARCINOMA (CLINICOPATHOLOGICAL STUDY).
Deban, M., El Didi, F., Ramadan, O. (2021). QUANTITATIVE ASSESSMENT OF TUMOR ASSOCIATED TISSUE EOSINOPHILIA IN ORAL SQUAMOUS CELL CARCINOMA (CLINICOPATHOLOGICAL STUDY).. EKB Journal Management System, 46(Issue 1), 72-77. doi: 10.21608/adjalexu.2020.21700.1034
Mohamed AZ Deban; Fatma Hassan El Didi; Omneya R. Ramadan. "QUANTITATIVE ASSESSMENT OF TUMOR ASSOCIATED TISSUE EOSINOPHILIA IN ORAL SQUAMOUS CELL CARCINOMA (CLINICOPATHOLOGICAL STUDY).". EKB Journal Management System, 46, Issue 1, 2021, 72-77. doi: 10.21608/adjalexu.2020.21700.1034
Deban, M., El Didi, F., Ramadan, O. (2021). 'QUANTITATIVE ASSESSMENT OF TUMOR ASSOCIATED TISSUE EOSINOPHILIA IN ORAL SQUAMOUS CELL CARCINOMA (CLINICOPATHOLOGICAL STUDY).', EKB Journal Management System, 46(Issue 1), pp. 72-77. doi: 10.21608/adjalexu.2020.21700.1034
Deban, M., El Didi, F., Ramadan, O. QUANTITATIVE ASSESSMENT OF TUMOR ASSOCIATED TISSUE EOSINOPHILIA IN ORAL SQUAMOUS CELL CARCINOMA (CLINICOPATHOLOGICAL STUDY).. EKB Journal Management System, 2021; 46(Issue 1): 72-77. doi: 10.21608/adjalexu.2020.21700.1034

QUANTITATIVE ASSESSMENT OF TUMOR ASSOCIATED TISSUE EOSINOPHILIA IN ORAL SQUAMOUS CELL CARCINOMA (CLINICOPATHOLOGICAL STUDY).

Alexandria Dental Journal
Article 11, Volume 46, Issue 1, April 2021, Page 72-77  XML PDF (170.01 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2020.21700.1034
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Authors
Mohamed AZ Deban email ; Fatma Hassan El Didi; Omneya R. Ramadanorcid
Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
Abstract
ABSTRACT
INTRODUCTION: Oral Squamous cell carcinoma (OSCC) is the 11th most common cancer worldwide. Tumor stroma consists of various inflammatory cells resulting from the host-response to tumor cell. Increased tissue eosinophil levels have been reported in various malignancies including OSCC. Tissue eosinophilia is a regular finding in allergic and parasitic disorders, but their role still needs to be evaluated in OSCCs. Specific stains as Congo red is a useful diagnostic means for detecting eosinophils owing to their distinctive quality to combine with eosinophils.
OBJECTIVES: was to evaluate and compare eosinophilic infiltration in both metastatic and non-metastatic oral squamous cell carcinoma using Congo red stain and their correlation to the tumor grade.
MATERIAL AND METHODS: Fifty histopathologically proven OSCC were included in this study and were allocated into 2 groups where the first group included 25 cases of metastatic OSCC and the remaining 25 cases are non-metastatic OSCC. Congo red was utilized as a distinct stain for eosinophils. Each specimen slide was inspected under high power in 10 successive microscopic fields to count eosinophils.
RESULTS: the eosinophilic count was found to be higher in non-metastatic tumors when compared to metastatic tumors.
CONCLUSION: eosinophilic count is a strong indicator of the stage of the tumor and its differentiation.
KEY WORDS: Carcinoma, Congo Red, Eosinophils, Eosinophilia, Mouth Neoplasms, Squamous Cell.
Keywords
Carcinoma; Congo Red; Eosinophils; Mouth Neoplasms; Squamous Cell
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