ANTIBIOTIC RESISTANCE OF ACINETOBACTER BAUMANNII: AN URGENT NEED FOR NEW THERAPY AND INFECTION CONTROL
Abd-ElNasser, R., Abdel-Rahim, M., Mahmoud, M., Elkhawaga, A., Hassnein, K. (2020). ANTIBIOTIC RESISTANCE OF ACINETOBACTER BAUMANNII: AN URGENT NEED FOR NEW THERAPY AND INFECTION CONTROL. EKB Journal Management System, 43(2), 265-279. doi: 10.21608/bfsa.2020.127991
Randa Abd-ElNasser; Mona Hussein Abdel-Rahim; Manal Ahmed Mahmoud; Amal Ahmed Elkhawaga; Khaled Mohamed Hassnein. "ANTIBIOTIC RESISTANCE OF ACINETOBACTER BAUMANNII: AN URGENT NEED FOR NEW THERAPY AND INFECTION CONTROL". EKB Journal Management System, 43, 2, 2020, 265-279. doi: 10.21608/bfsa.2020.127991
Abd-ElNasser, R., Abdel-Rahim, M., Mahmoud, M., Elkhawaga, A., Hassnein, K. (2020). 'ANTIBIOTIC RESISTANCE OF ACINETOBACTER BAUMANNII: AN URGENT NEED FOR NEW THERAPY AND INFECTION CONTROL', EKB Journal Management System, 43(2), pp. 265-279. doi: 10.21608/bfsa.2020.127991
Abd-ElNasser, R., Abdel-Rahim, M., Mahmoud, M., Elkhawaga, A., Hassnein, K. ANTIBIOTIC RESISTANCE OF ACINETOBACTER BAUMANNII: AN URGENT NEED FOR NEW THERAPY AND INFECTION CONTROL. EKB Journal Management System, 2020; 43(2): 265-279. doi: 10.21608/bfsa.2020.127991

ANTIBIOTIC RESISTANCE OF ACINETOBACTER BAUMANNII: AN URGENT NEED FOR NEW THERAPY AND INFECTION CONTROL

Bulletin of Pharmaceutical Sciences Assiut University
Article 16, Volume 43, Issue 2, December 2020, Page 265-279  XML PDF (637.59 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2020.127991
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Authors
Randa Abd-ElNasser1; Mona Hussein Abdel-Rahim2; Manal Ahmed Mahmoud3; Amal Ahmed Elkhawaga2; Khaled Mohamed Hassnein2
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt & Ministry of Health and Population, Assiut, Egypt
2Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt
3Department of Chest Diseases, Faculty of Medicine, Assiut University, Assiut, Egypt
Abstract
Acinetobacter baumannii (A. baumannii) infections became an emerging health concern in hospitals across the globe and are often related to nosocomial infections with poorer clinical outcomes in patients with prolonged hospital stay. Management of infections involves prompt identification of the infecting strain, isolating the source of infection, and proper choice of antibiotic regimen. However, resistance to first-line antimicrobial drugs, combined with a scarcity of equally effective alternatives, complicates the treatment of multidrug-resistant (MDR) A. baumannii. Presently, MDR A. baumannii may be a serious health concern in hospitals and long-term care facilities accounting for up to 20% of infections in intensive care units, and 7% of infections in patients who are physically connected to medical equipments. Immediate and sustained prevention efforts are needed to control the speed of incidence. Antibiotic use is largely under-regulated in Egypt leading to the emergence of resistant isolates. This review describes genetic markers and other factors that influence the incidence of MDR A. baumannii. Current and emerging treatments as well as infection control strategies are discussed.
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