The Role of Fractalkine/CX3CL1 in Children with Lupus Nephritis | ||||
| Zagazig University Medical Journal | ||||
| Article 590, Volume 29, Issue 1.2, January 2023, Page 254-260 PDF (373.86 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2020.48407.1995 | ||||
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| Authors | ||||
Alshymaa Alshymaa Ahmed   1; Ebtehag Helmy Hassan2; Hany Elsayed3; Asmaa M Alhussiny4
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| 1Faculty of Medicine, Zagazig University, Zagazig City, Al Sharqia Governorate, Egypt | ||||
| 2Department of clinical pathology, Faculty of Medicine, Zagazig University, Egypt | ||||
| 3Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig City, Al Sharqia Governorate, Egypt. | ||||
| 4Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig City, Al Sharqia Governorate, Egypt. | ||||
| Abstract | ||||
| Background:- renal biopsy the gold standard for diagnosing lupus nephritis (LN) is an invasive technique, other laboratory markers lack sensitivity and specificity. Aim:- to evaluate serum fractalkine (CX3CL1) as a predictor for LN in children with systemic lupus erythematosus (SLE). Methods:- forty four children “5 - 18 years old“ newly diagnosed with SLE, 22 (50.0%) of them were complicated with lupus nephritis “diagnosed by renal biopsy”, and 22 healthy age and sex matched children were included. Serum Fractalkine levels were determined using human CX3CL1 ELISA. Results:- healthy children had lower serum fractalkine levels (median: 950.56 pg/ml, range: 591.55-1583.29) than both patient groups p < 0.001, while there was no significant differences in between patients with LN (median: 1389.35 pg/ml, range 711.22– 16547.51) and without LN (median: 1429.39 pg/ml, range 591.55 – 4700.21), p=0.46. Moreover, serum Fractalkine was not correlated with the stage of LN (r=0.29, P=0.21) Conclusion:- Serum fractalkine is a poor predictor of lupus nephritis in children with SLE, although more studies are still required. | ||||
| Keywords | ||||
| Biomarkers; CX3CL1; Fractalkine; pediatric lupus nephritis; systemic lupus erythematosus | ||||
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