Ultrasound-Assisted Extraction of Damsin and Neoambrosin from Ambrosia maritima: Optimization Using Response Surface Methodology
Ali Abdeldayem, S., Khalil, M., Abdelrahman, E., El-Gohary, H., Yehia, A. (2021). Ultrasound-Assisted Extraction of Damsin and Neoambrosin from Ambrosia maritima: Optimization Using Response Surface Methodology. EKB Journal Management System, 64(3), 1433-1439. doi: 10.21608/ejchem.2020.47736.2989
Shymaa Ibrahim Ali Abdeldayem; Mohammed Nabil Ahmed Khalil; Enas Hussein Abdelrahman; Hamida Mohamed El-Gohary; Ali Yehia. "Ultrasound-Assisted Extraction of Damsin and Neoambrosin from Ambrosia maritima: Optimization Using Response Surface Methodology". EKB Journal Management System, 64, 3, 2021, 1433-1439. doi: 10.21608/ejchem.2020.47736.2989
Ali Abdeldayem, S., Khalil, M., Abdelrahman, E., El-Gohary, H., Yehia, A. (2021). 'Ultrasound-Assisted Extraction of Damsin and Neoambrosin from Ambrosia maritima: Optimization Using Response Surface Methodology', EKB Journal Management System, 64(3), pp. 1433-1439. doi: 10.21608/ejchem.2020.47736.2989
Ali Abdeldayem, S., Khalil, M., Abdelrahman, E., El-Gohary, H., Yehia, A. Ultrasound-Assisted Extraction of Damsin and Neoambrosin from Ambrosia maritima: Optimization Using Response Surface Methodology. EKB Journal Management System, 2021; 64(3): 1433-1439. doi: 10.21608/ejchem.2020.47736.2989

Ultrasound-Assisted Extraction of Damsin and Neoambrosin from Ambrosia maritima: Optimization Using Response Surface Methodology

Egyptian Journal of Chemistry
Article 32, Volume 64, Issue 3, March 2021, Page 1433-1439  XML PDF (569.94 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.47736.2989
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Authors
Shymaa Ibrahim Ali Abdeldayem email orcid 1; Mohammed Nabil Ahmed Khalilorcid 2; Enas Hussein Abdelrahmanorcid 3; Hamida Mohamed El-Goharyorcid 3; Ali Yehiaorcid 4
1Pharmacognosy,pharmacy,Cairo university, Cairo, Egypt
2Pharmacognosy Department, Faculty of Pharmacy, Cairo University. Pharmacognosy department, faculty of pharmacy, Heliopolis University for Sustainable Development
3Pharmacognosy Department, Faculty of Pharmacy, Cairo University
4Analytical Chemistry Department, Faculty of Pharmacy, Cairo University. Chemistry Department, School of Pharmacy and Pharmaceutical Industries, Badr University in Cairo (BUC)
Abstract
Damsin and neoambrosin are two important anticancer phytopharmaceuticals of Ambrosia maritima (Damsissa). Despite their importance, no report has yet discussed their extraction from plants on lab or industrial scales. Consequently, the present article aims to develop an ultrasonic-assisted extraction (UAE) model for their extraction on the lab scale. Box-Behnken model was applied to investigate the effects of ethanol strength (X1: 40-100%), drug solvent ratio (DSR, X2: 1:20-1:60), and time (X3: 30-90 min) on the yield of damsin and neoambrosin in damsissa extract. Surprisingly, only ethanol strength was the significant factor in damsin yield with an optimum value of 65%. Time and DSR played no significant roles in damsin content. No statistically significant model could be deduced for neoambrosin. The model is a preliminary step to elucidate factors affecting the UAE of sesquiterpene lactones from plants and a preamble for its large scale green extraction.
Keywords
Damsin; Neoambrosin; Ultrasonic-assisted extraction; response Surface method; sesquiterpene lactones; Ambrosia
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