Convenient Synthesis Of New Indeno[1,2-b]Pyridine Derivatives For Antimicrobial And Antioxidant Evaluation
Kotb, E., Soliman, H., Hassan, E., Negm El-Dein, A. (2021). Convenient Synthesis Of New Indeno[1,2-b]Pyridine Derivatives For Antimicrobial And Antioxidant Evaluation. EKB Journal Management System, 64(3), 1503-1515. doi: 10.21608/ejchem.2020.49035.3007
Eman Rashad Kotb; Hanan A Soliman; Eman Mostafa Hassan; Asmaa Negm El-Dein. "Convenient Synthesis Of New Indeno[1,2-b]Pyridine Derivatives For Antimicrobial And Antioxidant Evaluation". EKB Journal Management System, 64, 3, 2021, 1503-1515. doi: 10.21608/ejchem.2020.49035.3007
Kotb, E., Soliman, H., Hassan, E., Negm El-Dein, A. (2021). 'Convenient Synthesis Of New Indeno[1,2-b]Pyridine Derivatives For Antimicrobial And Antioxidant Evaluation', EKB Journal Management System, 64(3), pp. 1503-1515. doi: 10.21608/ejchem.2020.49035.3007
Kotb, E., Soliman, H., Hassan, E., Negm El-Dein, A. Convenient Synthesis Of New Indeno[1,2-b]Pyridine Derivatives For Antimicrobial And Antioxidant Evaluation. EKB Journal Management System, 2021; 64(3): 1503-1515. doi: 10.21608/ejchem.2020.49035.3007

Convenient Synthesis Of New Indeno[1,2-b]Pyridine Derivatives For Antimicrobial And Antioxidant Evaluation

Egyptian Journal of Chemistry
Article 39, Volume 64, Issue 3, March 2021, Page 1503-1515  XML PDF (466.45 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.49035.3007
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Authors
Eman Rashad Kotb email orcid 1; Hanan A Soliman2; Eman Mostafa Hassan3; Asmaa Negm El-Dein4
1Photochemistry Department, NRC
2Photochemistry deprtment, NRC
3Photochemistry department, NRC
4Chemistry of Natural and Microbial Products Department, Pharmaceutical Industries Researches Division, National Research Centre, Dokki, Egypt
Abstract
A new set of 1H-indenopyrdine-based derivatives were synthesized using the compound 4-(4-hydroxy-3-methoxyphenyl)-2-oxo-2,5-dihydro-1H-indeno[1,2-b]pyridine-3-carbonitrile (1) as the key starting compound. The molecular structures of the new derivatives were identified using various spectroscopic techniques and elemental analysis. All the new analogues were screened as antimicrobial against different strains of +ve gm, -ve gm bacteria and the opportunistic pathogenic yeast C. albicans. Some of the new indenopyrdines exhibited moderate antimicrobial activity comparing to gentamicin as a standard drug. On the reverse, the free radical scavenging activity of the new compounds using DPPH assay protocol revealed that most of the compounds were potent antioxidant agents while comparing to ascorbic acid as a positive antioxidant control.
Keywords
1H- indenopyrdine; Schiff’s bases; Thiazolidinone ring; Antimicrobial activity; Antioxidant
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