CLINICOPATHOLOGICAL STUDIES ON HEPATOPROTECTIVE EFFECT OF PENTOXIFYLLINE ON CCL4 INDUCED LIVER FIBROSIS IN GUINEA PIGS | ||||
| Mansoura Veterinary Medical Journal | ||||
| Article 3, Volume 17, Issue 2, June 2016, Page 283-295 | ||||
| DOI: 10.21608/mvmj.2016.129078 | ||||
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| Authors | ||||
| Fatma M.A1; El-Boshy M.E1; Hussein S.H2 | ||||
| 1Dept of Clinical Pathology, Fac. Vet. Med., Mansoura University | ||||
| 2Dept of Pathology, Fac. Vet. Med., Mansoura University. | ||||
| Abstract | ||||
| In this study, we investigate the protective and therapeutic effect of Pentoxifylline against liver damage induced by CCl4 in Guinea pigs by monitoring the hepatic m-RNA expression of TGFβ-1, ,some serum biochemical parameters and some oxidative stress biomarker. The CCl4 was orally administrated at dose 1 ml/kg bw twice a week for 8 weeks. Pentoxifylline orally administrated at a dose rate at dose 20 mg/kg bw/day. We found that Pentoxifylline treatment improved elevated m-RNA expression of TGFβ-1, ALT, T.Bil, D.Bil, MDA and SOD serum levels induced by CCl4 at 8th week post treatment. Meanwhile, AST and AP are not improved by Pentoxifylline treatment. Finally,We concluded that pentoxifylline is to somewhat effective in down regulation of chronic liver injury induced by CCl4 if used as protective treatment. | ||||
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