STEROID-INDUCED GLUCOSE INTOLERANCE IN CHILDREN WITH NEPHROTIC SYNDROME AND SYSTEMIC LUPUS ERYTHEMATOUS | ||||
| ALEXMED ePosters | ||||
| Article 40, Volume 2, Issue 2, October 2020, Page 72-72 | ||||
| Document Type: Preliminary preprint short reports of original research | ||||
| DOI: 10.21608/alexpo.2020.51386.1079 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Aisha Athia Kayonga 
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| Department of Pediatrics, faculty of medecine, Alexandria University. Alexandria, Egypte | ||||
| Abstract | ||||
| Steroids are the cornerstone in treatment of idiopathic nephrotic syndrome (INS) and systemic lupus erythematosus (SLE). Steroids are used for their anti-inflammatory and immunosuppressive effects. Although, they are known to cause serious adverse effects including glucose intolerance. The mechanisms by which steroid-induced glucose intolerance (SIGI) include: increased gluconeogenesis in the liver, reduced glucose uptake in adipose tissue and skeletal muscle, and induced pancreatic β-cell dysfunction. The exact prevalence of SIGI in patients on chronic steroid therapy is unknown. The prevalence was reported to vary between 0% and 65% and several risk factors for the developing SIGI have been identified. THE AIM OF THIS WORK The aim of this work was to study steroid-induced glucose intolerance in patients with idiopathic nephrotic syndrome and systemic lupus erythematosus on long term steroid treatment and to determine the risk factors associated with development of steroid-induced glucose intolerance. SUBJECTS Subjects were recruited directly from outpatient Pediatric Nephrology Clinic. Sixty children aged from 2 to 18 years were enrolled; including 2 groups: thirty patients with INS and thirty patients with SLE on long-term steroids use for at least 6 months. | ||||
| Keywords | ||||
| Steroid; glucose intolerance; children | ||||
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