Protective Effects of α-lipoic acid on Biological changes Induced by α- cypermethrin in Testis Rats | ||||
| Journal of Bioscience and Applied Research | ||||
| Article 1, Volume 4, Issue 2, June 2018, Page 84-97 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbaar.2018.129883 | ||||
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| Authors | ||||
| A. Sedky1; A. Ali2 | ||||
| 1College of Science, King Faisal University, Al-Ahsaa, Hufof 31982, Saudi Arabia/Zoology Department - Faculty of Science, Alexandria University | ||||
| 2Zoology Department - Faculty of Science, Alexandria University, Egypt | ||||
| Abstract | ||||
| Abstract a-cypermethrin is one of the most potent insecticides used worldwide. This study was planned to evaluate the possible role of a-lipoic acid in a-cypermethrin induced toxicity in rats. The treated groups were; the control, α-cypermethrin, a-lipoic acid and a-cypermethrin, and a-lipoic acid groups. Our results showed that administration of a-cypermethrin caused a significant decrease in RBC count, PCV, and Hb content and an increase in WBC count. Also, a- cypermethrin caused a significant increase in the levels of cholesterol, TGs, LDL-Cand VLDL-C, while the HDL-C was decreased. Also, a-cypermethrin caused a reduction in serum testosterone, FSH, and LH levels in intoxicated rats. Furthermore, the co-administration of a-lipoic acid mitigated the toxicity of a-cypermethrin by partially normalizing these biochemical parameters. Our results were supported by histopathological observations of the testis. Our data suggest that a-lipoic acid may have a protective role against a-cypermethrin induced toxicity in rats. | ||||
| Keywords | ||||
| α--cypermethrin; toxicity; blood; testis; α--lipoic acid | ||||
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