Clinical Manifestations of Philadelphia-negative Myeloproliferative Neoplasms in Sudan
Elbager, S., Abdelgader, E., Ali, S., Mursal, T., Yousif, N., Osman, E., Dowd, A., Bayoumi, M. (2018). Clinical Manifestations of Philadelphia-negative Myeloproliferative Neoplasms in Sudan. EKB Journal Management System, 4(2), 98-105. doi: 10.21608/jbaar.2018.129897
Sahar Elbager; Enaam Abdelgader; Samah Ali; Tahani Mursal; Nahid Yousif; Eltaher Osman; Amar Dowd; Magdi Bayoumi. "Clinical Manifestations of Philadelphia-negative Myeloproliferative Neoplasms in Sudan". EKB Journal Management System, 4, 2, 2018, 98-105. doi: 10.21608/jbaar.2018.129897
Elbager, S., Abdelgader, E., Ali, S., Mursal, T., Yousif, N., Osman, E., Dowd, A., Bayoumi, M. (2018). 'Clinical Manifestations of Philadelphia-negative Myeloproliferative Neoplasms in Sudan', EKB Journal Management System, 4(2), pp. 98-105. doi: 10.21608/jbaar.2018.129897
Elbager, S., Abdelgader, E., Ali, S., Mursal, T., Yousif, N., Osman, E., Dowd, A., Bayoumi, M. Clinical Manifestations of Philadelphia-negative Myeloproliferative Neoplasms in Sudan. EKB Journal Management System, 2018; 4(2): 98-105. doi: 10.21608/jbaar.2018.129897

Clinical Manifestations of Philadelphia-negative Myeloproliferative Neoplasms in Sudan

Journal of Bioscience and Applied Research
Article 2, Volume 4, Issue 2, June 2018, Page 98-105  XML PDF (275.79 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2018.129897
View on SCiNiTO View on SCiNiTO
Authors
Sahar Elbager email 1; Enaam Abdelgader2; Samah Ali1; Tahani Mursal1; Nahid Yousif2; Eltaher Osman3; Amar Dowd1; Magdi Bayoumi4
1Faculty of Medical Laboratory Sciences, University of Medical Sciences and Technology (UMST), Sudan
2Radiation and Isotope Center - Khartoum (RICK), Sudan
3Sudan Medical and & Scientific Research Institute (SUMASRI) University of Medical Sciences and Technology (UMST), Sudan
4Faculty of Medical Laboratory Sciences, University of Medical Sciences and Technology (UMST), Sudan/Sudan Medical and & Scientific Research Institute (SUMASRI) University of Medical Sciences and Technology (UMST), Sudan
Abstract
Background/ objective: The Philadelphia-negative chronic myeloproliferative neoplasms (MPNs), is a heterogeneous group of oncohematological diseases that express a high burden of symptoms that significantly affect patient quality of life and are associated with high morbidity and premature mortality. This study aimed to determine the clinical manifestations of MPNs in the Sudanese population. Method: A retrospective study was carried out in the Radiation and Isotope Center at Khartoum (RICK), Sudan. 290 medical records of MPNs were examined. Results: Polycythemia Vera (PV) was the most frequent (64.1%) with a median age at diagnosis of 50 years. It was, followed by Essential Thrombocythemia (ET) (28.6%, median age 48years) and Primary Myelofibrosis (PMF) (7.3%, median age 58years). Male patients had mostly a history of PV (p < 0.05). Females were predominately affected by ET (p < 0.05), despite the gender distribution of PMF patients was approximately similar (p > 0.05). Among PV cases, the main symptoms present at diagnosis were fatigue with fever reported by 31.2% of cases followed by headache (26.6%), joint pain (24.2%), splenomegaly (14.2%), hepatosplenomegaly, and thrombotic complications. In ET, 43.4% of the cases complained about headache followed by fatigue associated with fever, joint pain, splenomegaly, hepatosplenomegaly. None of the ET cases presented bleeding or thrombotic complications. In PMF cases, the main symptoms were fatigue with fever (19%) followed by joint pain, headache, fever, bleeding, thrombotic complication, splenomegaly, hepatosplenomegaly.
Conclusion: The current study showed that in Sudan, MPNs affect a younger population and PV was more prevalent than ET and PMF. The findings also revealed that headache, fatigue, and joint pain were the most frequent symptoms
Keywords
Clinical Manifestations; Essential Thrombocythemia; Polycythemia Vera; Primary Myelofibrosis; Sudan
Statistics
Article View: 142
PDF Download: 189