A New Insight into Pleiogynium timorense Leaves: A Focus on The Anticancer and Antimicrobial Potentials
Abdel Raoof, G., Said, A., Ismail, S., El-anssary, A. (2021). A New Insight into Pleiogynium timorense Leaves: A Focus on The Anticancer and Antimicrobial Potentials. EKB Journal Management System, 64(3), 1541-1551. doi: 10.21608/ejchem.2020.52093.3070
Gehan Fawzy Abdel Raoof; Ataa Said; Shaymaa Ismail; Amira A El-anssary. "A New Insight into Pleiogynium timorense Leaves: A Focus on The Anticancer and Antimicrobial Potentials". EKB Journal Management System, 64, 3, 2021, 1541-1551. doi: 10.21608/ejchem.2020.52093.3070
Abdel Raoof, G., Said, A., Ismail, S., El-anssary, A. (2021). 'A New Insight into Pleiogynium timorense Leaves: A Focus on The Anticancer and Antimicrobial Potentials', EKB Journal Management System, 64(3), pp. 1541-1551. doi: 10.21608/ejchem.2020.52093.3070
Abdel Raoof, G., Said, A., Ismail, S., El-anssary, A. A New Insight into Pleiogynium timorense Leaves: A Focus on The Anticancer and Antimicrobial Potentials. EKB Journal Management System, 2021; 64(3): 1541-1551. doi: 10.21608/ejchem.2020.52093.3070

A New Insight into Pleiogynium timorense Leaves: A Focus on The Anticancer and Antimicrobial Potentials

Egyptian Journal of Chemistry
Article 42, Volume 64, Issue 3, March 2021, Page 1541-1551  XML PDF (569.73 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.52093.3070
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Authors
Gehan Fawzy Abdel Raoof email orcid 1; Ataa Said2; Shaymaa Ismailorcid 3; Amira A El-anssary4
1Pharmacognosy Department, Pharmaceutical and Drug Research Industries Division, National Research Centre, Cairo, Egypt
2Pharmacognosy Department, Pharmaceutical Science Division, National Research Centre,
3Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries, National Research Centre, Cairo, Egypt.
4Pharmacognosy Department, Pharmaceutical and Drug Research Industries Division, National Research Centre, Cairo,Egypt
Abstract
The current study focused on the anticancer and antimicrobial potentials of the ethyl acetate extract of Pleiogynium timorense leaves and the characterization of its phytoconstituents. Ethyl acetate extract of pleiogynium timorense leaves showed a potent cytotoxic activity against ovarian cancer cell line (SKOV-3) with IC50 of (7.13 μg/mL) and a moderate activity against liver cancer cell line (HEPG-2) with IC50 =20.42 μg/mL , while it possessed a weak activity against Prostate cancer cell line (PC-3) (IC50 >100 μg/mL). In addition, the extract exhibited reasonable antibacterial activity against Staphylococcus aureus, Bacillus cereus, and Escherichia coli with MIC values of (200, 500 and 500 mg/ml), respectively without the detection of any activity against Salmonella typhimurium, Candida albicans and Aspergillus brasiliensis. The phytochemical study revealed the identification of eleven polyphenolic compounds representing 80.8 % of the total area; the major compounds were chlorogenic acid (40.8 %), gallic acid (11.1%), catechin (8.2%) and taxifolin (7.6 %). Moreover, gallic acid, kaempeferol and catechin were isolated and identified for the first time from the ethyl acetate extract. In addition, the plant extract is found to be rich in natural pigments (total carotenoids = 864.64 g/100g). In conclusion, the current study revealed that ethyl acetate extract of Pleiogynium timorense leaves is rich with polyphenolic compounds, which play a vital role in the plant bioactivities.
Keywords
Pleiogynium timorense leaves; cytotoxic; antimicrobial; phytoconstituents
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