Visfatin in Association with Severity and Activity of Primary Osteoarthritis and Rheumatoid Arthritis
Allam, D., Shams El Din, A., El Shambaky, A., Yehia, M. (2021). Visfatin in Association with Severity and Activity of Primary Osteoarthritis and Rheumatoid Arthritis. EKB Journal Management System, 38(1), 113-124. doi: 10.21608/bmfj.2020.130408
Dalia Allam; Abd El Wahab Shams El Din; Ahmed El Shambaky; Marwa Yehia. "Visfatin in Association with Severity and Activity of Primary Osteoarthritis and Rheumatoid Arthritis". EKB Journal Management System, 38, 1, 2021, 113-124. doi: 10.21608/bmfj.2020.130408
Allam, D., Shams El Din, A., El Shambaky, A., Yehia, M. (2021). 'Visfatin in Association with Severity and Activity of Primary Osteoarthritis and Rheumatoid Arthritis', EKB Journal Management System, 38(1), pp. 113-124. doi: 10.21608/bmfj.2020.130408
Allam, D., Shams El Din, A., El Shambaky, A., Yehia, M. Visfatin in Association with Severity and Activity of Primary Osteoarthritis and Rheumatoid Arthritis. EKB Journal Management System, 2021; 38(1): 113-124. doi: 10.21608/bmfj.2020.130408

Visfatin in Association with Severity and Activity of Primary Osteoarthritis and Rheumatoid Arthritis

Benha Medical Journal
Article 10, Volume 38, Issue 1, April 2021, Page 113-124  XML PDF (733.06 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.130408
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Authors
Dalia Allam; Abd El Wahab Shams El Din; Ahmed El Shambaky; Marwa Yehia
Department of Rheumatology, Rehabilitation and physical medicine, Benha faculty of medicine , Benha University, Egypt
Abstract
Background: Visfatin is a one of the recently discovered adipokine that has important pro-inflammatory and catabolic roles in rheumatoid arthritis (RA). Pro-inflammatory cytokines initiate a number of physiological changes that result in the characteristic signs of inflammation. Visfatin may play a role in OA by activating chondrocytes. Along with its cytokine effect, visfatin has an enzymatic activity called nicotinamide-phosphoribosyl-transferase (NAMPT). Objectives: To study the level of Visfatin in RA and OA sera and correlate its levels with activity and severity scores of both diseases. Subjects and methods: A case control study was conducted to assess Visfatin serum level in 20 patients of osteoarthritis and 25 patients rheumatoid arthritis and 20 apparently healthy individuals. Lequesne’s algo-functional Index used for assessment of OA functional impairment , Kellgren and  Lawrence  for radiological severity and KOFUS for activity , while Larsen's scoring system used for assessment of RA severity and DAS 28 score for activity. Visfatin concentrations in serum measured using a commercially available ELISA kit. Results: Mean Lequesne’s index was 11.2 ± 3.6. According to Kellgren and Lawrence we had one patient G1 , 9 patients GII , 7 patients GIII and 3 patients GIV .Median KOFUS was 5 and it ranged from 3 to 13,. Mean DAS 28 was 4.96± 1.27.  As regards Larsen score, mean was 24± 22. There was an overall significance in visfatin between three groups. P value was Conclusion: Visfatin may have a role in the pathogenesis of OA and RA. Furthermore it acts as a potential marker for disease activity and severity of RA as well as severity of OA.
Keywords
Visfatin; Rheumatoid arthritis(RA); Osteoarthritis (OA); ELISA kit
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