EVALUATION OF ANGIOPOIETIN-2 AS AN EARLY MARKER FOR DIABETIC NEPHROPATHY INZAGAZIG UNIVERSITY HOSPITALS | ||||
| Zagazig University Medical Journal | ||||
| Article 1, Volume 24, Issue 2, March 2018, Page 93-101 PDF (736.33 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2018.13082 | ||||
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| Authors | ||||
| Mohammad Hassan Aly; Mohammad Abbas Arafat; Ola Aly Hussein; Hanaa Hosny; Ayman Riyad Abdel-Hammed El Sayed | ||||
| Abstract | ||||
| ABSTRACT Background: To assess the validity of measuring plasma Angiopoietin as a biomarker for early detection of diabetic nephropathy and todetermine the relation between plasma Ang-2 and inflammation in diabetic nephropathy patients in Zagazig university Hospitals. Subjects and methods:This study included a total of 76 diabetic patients divided to microalbuminuria and macroalbuminuria groups , each group contained 38 patients in addition to 40 healthy control subjects. Results: Plasma levels of Ang-2 was significantly higher in patients with microalbuminuria and macroalbuminuria compared to healthy controls. Indeed, Ang-2 levels steadily increases with the progression of albuminuria . The study showed significant positive correlation between plasma Ang-2 , MAP and creatinine, uric acid, phosphorus, CRP, total cholesterol and triglycrides . We observed also significant negative correlation between plasma Ang-2 and Hb, eGFR, serum calcium and albumin. Conclusion:Our results indicated that Plasma Angiopoietin-2 levels are elevated in patients with diabetic nephropathy . plasma Ang-2 steadily increase with the progression of albuminuria, suggesting their possible role as early markers of microvascular angiopathy of glomeruli . Plasma Ang-2 is related to CRP, this implies that elevated levels of this biomarker occur as a result of inflammation and vascular dysfunction as a part of atherosclerotic process. Abbreviations: Ang-2 =Angiopoietin-2, CRP = C-reactive protein, Hb= hemoglobin, ACR = albumin-creatinine ratio, ESRD = end stage renal disease, MAP= mean arterial pressure, FBS = fasting blood suger. | ||||
| Keywords | ||||
| Angiopoietin; Diabetes mellitus | ||||
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