ASSESSMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE ALTERATIONS IN THE BRAIN IN A MOUSE MODEL OF VISCERAL LARVA MIGRANS
ELGENDY, D., OTHMAN, A., SAIED, E., ZOGHROBAN, H. (2020). ASSESSMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE ALTERATIONS IN THE BRAIN IN A MOUSE MODEL OF VISCERAL LARVA MIGRANS. EKB Journal Management System, 50(3), 467-476. doi: 10.21608/jesp.2020.130833
DINA ELGENDY; AHMAD OTHMAN; EMAN SAIED; HAGER ZOGHROBAN. "ASSESSMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE ALTERATIONS IN THE BRAIN IN A MOUSE MODEL OF VISCERAL LARVA MIGRANS". EKB Journal Management System, 50, 3, 2020, 467-476. doi: 10.21608/jesp.2020.130833
ELGENDY, D., OTHMAN, A., SAIED, E., ZOGHROBAN, H. (2020). 'ASSESSMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE ALTERATIONS IN THE BRAIN IN A MOUSE MODEL OF VISCERAL LARVA MIGRANS', EKB Journal Management System, 50(3), pp. 467-476. doi: 10.21608/jesp.2020.130833
ELGENDY, D., OTHMAN, A., SAIED, E., ZOGHROBAN, H. ASSESSMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE ALTERATIONS IN THE BRAIN IN A MOUSE MODEL OF VISCERAL LARVA MIGRANS. EKB Journal Management System, 2020; 50(3): 467-476. doi: 10.21608/jesp.2020.130833

ASSESSMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE ALTERATIONS IN THE BRAIN IN A MOUSE MODEL OF VISCERAL LARVA MIGRANS

Journal of the Egyptian Society of Parasitology
Article 1, Volume 50, Issue 3, December 2020, Page 467-476  XML PDF (1.3 MB)
Document Type: Original Article
DOI: 10.21608/jesp.2020.130833
View on SCiNiTO View on SCiNiTO
Authors
DINA ELGENDY1; AHMAD OTHMAN1; EMAN SAIED2; HAGER ZOGHROBAN1
1Department of Medical Parasitology, Faculty of Medicine, Tanta University. Egypt
2Department of Pathology, Faculty of Medicine, Kafrelsheikh University. Egypt
Abstract
Neurotoxocariasis is a parasitic zoonosis resulting from the intrusion of the larvae of dog
roundworm Toxocara canis into the central nervous system (CNS), leading to severe CNS insults,
and provoking different neurological manifestations ranging from headache to convulsions
and paresis. This work assessed the probable occurrence of neuroinflammatory and neuro-degenerative
alterations in the brain tissues of T. canis infected mice and evaluated the changes in
brain parasite loads over the course of infection. The total larval loads in the brain, histopathological,
immunohistochemical (MMP-3 & MMP-9) examination as well as determination of NFcell
infiltration around larvae in brain tissues of mice, expressions of all the investigated markers
of neuroinflammation and neurodegeneration showed an ascending pattern throughout the
course of the infection and were directly proportional to the increase in the brain larval loads.
Keywords
Neurotoxocariasis; Neuroinflammation; Neurodegeneration; MMP-3; MMP-9; NF-; Tau protein
Statistics
Article View: 154
PDF Download: 232