Significance of Expression of IMP3, PPARG & PD-L1 in Urothelial Carcinoma (Immunohistochemical Study)
El Sawi, R., Abdel Aal, E., Zafer, N., Agina, H., El-Sebaaie, A. (2021). Significance of Expression of IMP3, PPARG & PD-L1 in Urothelial Carcinoma (Immunohistochemical Study). EKB Journal Management System, 38(Academic issue), 112-127. doi: 10.21608/bmfj.2020.130876
Rasha El Sawi; Ebtehal Abdel Aal; Nehal Zafer; Hala Agina; Amr El-Sebaaie. "Significance of Expression of IMP3, PPARG & PD-L1 in Urothelial Carcinoma (Immunohistochemical Study)". EKB Journal Management System, 38, Academic issue, 2021, 112-127. doi: 10.21608/bmfj.2020.130876
El Sawi, R., Abdel Aal, E., Zafer, N., Agina, H., El-Sebaaie, A. (2021). 'Significance of Expression of IMP3, PPARG & PD-L1 in Urothelial Carcinoma (Immunohistochemical Study)', EKB Journal Management System, 38(Academic issue), pp. 112-127. doi: 10.21608/bmfj.2020.130876
El Sawi, R., Abdel Aal, E., Zafer, N., Agina, H., El-Sebaaie, A. Significance of Expression of IMP3, PPARG & PD-L1 in Urothelial Carcinoma (Immunohistochemical Study). EKB Journal Management System, 2021; 38(Academic issue): 112-127. doi: 10.21608/bmfj.2020.130876

Significance of Expression of IMP3, PPARG & PD-L1 in Urothelial Carcinoma (Immunohistochemical Study)

Benha Medical Journal
Article 8, Volume 38, Academic issue, February 2021, Page 112-127  XML PDF (1.12 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.130876
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Authors
Rasha El Sawi1; Ebtehal Abdel Aal2; Nehal Zafer2; Hala Agina2; Amr El-Sebaaie3
1Department of pathology, Benha faculty of medicine, Benha University, Egypt.
2Department of pathology, Benha faculty of medicine, Benha University, Egypt
3Department of pathology Military Medical Academy, cairo, Egypt
Abstract
Background: IMP3, PPARG and PD-L1 have been implicated in tumorigenesis and progression in many cancers, but their significance in urothelial carcinoma remains unclear. Aim: The aim of this study is to assess the possible significance of IMP3, PPARG and PD-L1 in urothelial bladder carcinoma and determine the relation between their expressions and different clinicopathological (tumor size, grade, histological variant, muscle invasion, lymphovascular invasion and pathologic T stage) and molecular variables. Methods: This study aimed to evaluate immunohistochemical expression of IMP3, PPARG and PD-L1 and correlate them with clinicopathological and molecular variables. Results: IMP3 was significantly correlated to muscle invasion (P<0.01), tumor grade (P<0.05), histological variant (P<0.05), lymphovascular invasion (P<0.01) and PT stage (P<0.01). PPARG was inversely correlated to muscle invasion (P<0.01), tumor grade (P<0.01), histological variant (P<0.01), PT stage (P<0.05) and molecular subtype (P<0.01).  PD-L1 was significantly correlated to muscle invasion (P<0.05), histological variant (P<0.05) and PT stage (P<0.01). IMP3 and PD-L1 showed high statistically significant correlation (P<0.01). IMP3 and PPARG showed inverse statistically significant correlation (P<0.05). No significant correlation between PPARG and PD-L1expression was detected (P>0.05).Conclusions: IMP3 may be used as a prognostic marker. PPARG may be used to identify the luminal molecular subtype. PD-L1 may be used as a prognostic marker for tumor aggressiveness, so it may be used in immunotherapy.
Keywords
Urothelial carcinoma; IMP3; PPARG; PD-L1
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