PROGNOSTIC IMPACT OF PRETREATMENT FIB-4 INDEX AFTER RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA | ||||
Journal of the Egyptian Society of Parasitology | ||||
Article 17, Volume 50, Issue 3, December 2020, Page 605-612 PDF (823.44 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jesp.2020.131093 | ||||
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Authors | ||||
EFFAT A. MONEM1; MOHAMED EL-GHARIB2; AHMED SAYED1; ASHRAF M. ALBREEDY1 | ||||
1Departments of Tropical Medicine | ||||
2Departments of Radiodiagnosis, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt | ||||
Abstract | ||||
Intrahepatic distant recurrence, after successful radiofrequency ablation for hepatocellular carcinoma, is related to many factors. Underlying liver fibrosis/cirrhosis severity thought to be one of these contributors. FIB-4 index is a non-invasive marker which reflects the severity of liver fibrosis. The aim of this study was to evaluate the prognostic value of FIB-4 index after radiofrequency ablation for hepatocellular carcinoma with curative intent. This retrospective study included 121 HCV related hepatocellular carcinoma patients with Child class A who underwent radiofrequency ablation between 1/2010 & 12/2014. The study assessed the overall survival and denovo intrahepatic distant recurrence using pretreatment FIB-4 index. The result showed that pretreatment FIB-4 index of ≤3.25 patients had significant better free intrahepatic distant recurrence and overall survival rates after radiofrequency ablation when compared to those with pretreatment FIB-4 index of > 3.25, even in subsets of patients with Child score 5, single lesion or lesions< 3cm. Also, FIB-4 index was useful prognostic predictor of intrahepatic distant recurrence and overall survival after radiofrequency ablation in Child class A patients in uni and multivraite analysis. | ||||
Keywords | ||||
FIB-4 index; Hepatocellular carcinoma; Intrahepatic distant recurrence; Non- invasive fibrosis markers; Radiofrequency ablation | ||||
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