URINE AND SERUM SOLUBLE INTERLEUKIN 7 RECEPTOR LEVELS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AT ZAGAZIG UNIVERSITY HOSPITALS
El-Sheikh, M., Abd-El-Ghany, F., Abo Elmagd, Y., Hafeez Mohamed, R. (2018). URINE AND SERUM SOLUBLE INTERLEUKIN 7 RECEPTOR LEVELS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AT ZAGAZIG UNIVERSITY HOSPITALS. EKB Journal Management System, 24(4), 322-328. doi: 10.21608/zumj.2018.13222
Mazen Mohamed El-Sheikh; Fadya Abd-Allah Abd-El-Ghany; Yousry Elsaid Abo Elmagd; Rofaida Abdel Hafeez Mohamed. "URINE AND SERUM SOLUBLE INTERLEUKIN 7 RECEPTOR LEVELS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AT ZAGAZIG UNIVERSITY HOSPITALS". EKB Journal Management System, 24, 4, 2018, 322-328. doi: 10.21608/zumj.2018.13222
El-Sheikh, M., Abd-El-Ghany, F., Abo Elmagd, Y., Hafeez Mohamed, R. (2018). 'URINE AND SERUM SOLUBLE INTERLEUKIN 7 RECEPTOR LEVELS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AT ZAGAZIG UNIVERSITY HOSPITALS', EKB Journal Management System, 24(4), pp. 322-328. doi: 10.21608/zumj.2018.13222
El-Sheikh, M., Abd-El-Ghany, F., Abo Elmagd, Y., Hafeez Mohamed, R. URINE AND SERUM SOLUBLE INTERLEUKIN 7 RECEPTOR LEVELS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AT ZAGAZIG UNIVERSITY HOSPITALS. EKB Journal Management System, 2018; 24(4): 322-328. doi: 10.21608/zumj.2018.13222

URINE AND SERUM SOLUBLE INTERLEUKIN 7 RECEPTOR LEVELS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AT ZAGAZIG UNIVERSITY HOSPITALS

Zagazig University Medical Journal
Article 6, Volume 24, Issue 4, July 2018, Page 322-328  XML PDF (964.57 K)
Document Type: Original Article
DOI: 10.21608/zumj.2018.13222
View on SCiNiTO View on SCiNiTO
Authors
Mazen Mohamed El-Sheikh; Fadya Abd-Allah Abd-El-Ghany; Yousry Elsaid Abo Elmagd; Rofaida Abdel Hafeez Mohamed
Abstract
Background: Soluble interleukin 7 receptor (sIL7R) is secreted by fibroblasts after stimulation with proinflammatory cytokines. SIL7R  has been implicated in many autoimmune diseases  such as rheumatoid arthritis (RA) , inflammatory bowel diseases (IBD) and graft-versus-host disease (GVHD).
Objectives: we aimed to evaluate urine and serum  sIL7R levels in patients with systemic lupus erythematosus  and their association  with the disease activity.
Subjects and methods: For a case control study,  54 patients with  systemic lupus erythematosus and  27 age and sex matched healthy controls were involved. Serum and urine sIL7R levels (ng/mL) were determined by a sandwich ELISA kit. Disease activity was measured by SLE disease activity index (SLEDAI) score, complement C3, C4 levels and anti-dsDNA titre.
Results: Serum sIL7R levels were  significantly higher in SLE patients (p<0.0001) than in control group . Patients with lupus nephritis had significantly higher serum levels of sIL7R  than those without nephritis . There was significant correlation between sIL7R  levels and SLE disease activity including SLEDAI, C3,C4, anti dsDNA. Urine levels of sIL7R showed non-significant difference between SLE  patients and control group and did not correlate with disease activity.
Conclusions: Serum sIL7R is a valuable marker of SLE disease activity, especially in patients with lupus nephritis.
Keywords
Systemic lupus erythematosus; soluble interleukin 7 receptors; SLEDAI
Statistics
Article View: 240
PDF Download: 328