Helicobacter Pylori in Pediatrics | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 31, Volume 68, Issue 1, July 2017, Page 1075-1081 PDF (288.56 K) | ||||
Document Type: Original Article | ||||
DOI: 10.12816/0038212 | ||||
View on SCiNiTO | ||||
Authors | ||||
Wafaa M. Alsbhani1; Z. Sindi Basam2; Mohammed S. Dumyati2; Anwar A. F Alammari3; Shorooq A. Alenzi4; Sulafa T. Sindi3; Njood W. Nazer3; Abrar H. hakami5; Omar M. Maimsh3; Anas H. Alzahrani3; Mashael B. Alrubaian6; Kawkab A. hammam7; Ahad A. Alsharief8; Ali M. Alshubaily9; Hailah H. AlQarni9; Weaam S. Magram3 | ||||
1Ibn Sina national college for medical studies | ||||
2Umm Al-Qura University | ||||
3King Abdul-Aziz University | ||||
4Taibah University, Medina | ||||
5Jazan University | ||||
6Almaarefa Colleges for Science & Technology (MCST) | ||||
7Assuit University, Egypt | ||||
8Maternity & Children's Hospital in Makkah (MCH in Makkah) | ||||
9King Abdul-Aziz Hospital | ||||
Abstract | ||||
This review includes the main pediatric studies published from April 2011 to march 2016. The important studies involving H. pylori genomes, especially those pertaining to genomic diversity, disease outcome, H. pylori population structure and evolution are reviewed. Genotypic variability in H. pylori strains influences the clinical manifestation of the infection. The antigen stool test is becoming the “gold standard” in prevalence studies, and according to the epidemiologic studies, the prevalence of H. pylori in childhood is not decreasing any more in the developed world. Studies showed conflicting results regarding the association between H. pylori infection and iron deficiency anemia. One study suggests that H. pylori eradication plays a role in the management of chronic immune thrombocytopenic purpura. The prevalence of H. pylori was higher in chronic urticaria patients and following H. pylori eradication, urticarial symptoms disappeared. An inverse relationship between H. pylori infection and allergic disease was reported. The resistance rate of H. pylori strains is high in children. Therefore, among other important issues concerning H. pylori in pediatrics, guidelines published by ESPGHAN and NASPGHAN last year also recommended culture and susceptibility testing before first-line treatment in areas with high or unknown antibiotic resistance rates. | ||||
Keywords | ||||
Helicobacter pylori; H pylori; Infection; Pediatrics | ||||
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