N-acetylecysteine: The multiuse antioxidant
Ali, W., Mahmoud, W., Shafik, N., Khalaf, A., Ahmed, H., Mahmoud, A. (2021). N-acetylecysteine: The multiuse antioxidant. EKB Journal Management System, 25(1), 41-45. doi: 10.21608/smj.2020.44346.1203
Wafaa Abdelghaffar Ali; Wael Alham Mahmoud; Noha Saber Shafik; Asmaa Mohammed Khalaf; Hassnaa Ahmed Ahmed; Ahmed Alamir Mahmoud. "N-acetylecysteine: The multiuse antioxidant". EKB Journal Management System, 25, 1, 2021, 41-45. doi: 10.21608/smj.2020.44346.1203
Ali, W., Mahmoud, W., Shafik, N., Khalaf, A., Ahmed, H., Mahmoud, A. (2021). 'N-acetylecysteine: The multiuse antioxidant', EKB Journal Management System, 25(1), pp. 41-45. doi: 10.21608/smj.2020.44346.1203
Ali, W., Mahmoud, W., Shafik, N., Khalaf, A., Ahmed, H., Mahmoud, A. N-acetylecysteine: The multiuse antioxidant. EKB Journal Management System, 2021; 25(1): 41-45. doi: 10.21608/smj.2020.44346.1203

N-acetylecysteine: The multiuse antioxidant

Sohag Medical Journal
Article 6, Volume 25, Issue 1, January 2021, Page 41-45  XML PDF (420.15 K)
Document Type: Original Article
DOI: 10.21608/smj.2020.44346.1203
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Authors
Wafaa Abdelghaffar Ali email 1; Wael Alham Mahmoud2; Noha Saber Shafik3; Asmaa Mohammed Khalaf4; Hassnaa Ahmed Ahmed4; Ahmed Alamir Mahmoud5
1forensic medicine and clinical toxicology faculty of medicine sohag university
2anaesthesia and intensive care ,faculty of medicine, sohag university
3medical microbiology and immunology
4forensic medicine and clinical toxicology, faculty of medicine, sohag university
5medical biochemistry, faculty of medicine, sohag university
Abstract
N-acetylcysteine (NAC) is an acetylated variant of the amino acid L-cysteine, is an effective antidote able to increase cell protection against oxidative stress , it acts as an antioxidant by restoring the pool of intracellular reduced glutathione, which is often depleted as a consequence of increased status of oxidative stress and inflammation. It has reducing and antioxidant properties, acting as a direct scavenger of ROS (reactive oxygen species).
NAC is available in different dosage forms for different indications.
Many studies stated other uses of NAC such as mucolytic action which is useful in obstructive airway , nasal sinus diseases as it liquefies bacterial biofilms ( antibacterial action), decrease radio contrast induced kidney disease, treatment of many neuropsychiatric diseases like Alzheimer's disease, bipolar disorder, major depressive disorder, obsessive-compulsive disorder, schizophrenia, specific drug addictions (cocaine) and a certain form of epilepsy (progressive myoclonic) through central mechanisms, and improved fertility outcome in both males and females.
Keywords
N-acetylcysteine; Reactive oxygen species; Biologic antioxidant; Glutathione
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