Role of Glucose-Insulin-Potassium solution for myocardial protection during open-heart surgery | ||||
| Sohag Medical Journal | ||||
| Article 7, Volume 25, Issue 1, January 2021, Page 46-49 PDF (347.88 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/smj.2020.47877.1210 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ahmed Elsaied Abd Elrahman1; Essam Ezzat Abd El-hakeem2; Osama Salah El-Din Mahmoud  3; Ahmad hamody Hassan4
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| 1department of anesthesia, faculty of medicine, sohag university | ||||
| 2Department of Anesthesia and intensive care, faculty of medicine, Assiut university | ||||
| 3Department of Anesthesia and Intensive Care, faculty of medicine, Sohag University | ||||
| 4Department of Anesthesia and intensive care, faculty of medicine, Sohag university | ||||
| Abstract | ||||
| The purpose of this review was to verify the function and potential mechanisms of glucose-insulin-potassium (GIK) solution infusion in cardiac surgery with regard to cardiac protection. Myocardial damage is associated with cardiac surgical procedures involving hypothermic cardiac arrest and cardiopulmonary bypass (CPB). One of the most critical targets for cardiac surgery during anesthesia is to reduce myocardial damage. In terms of cardiac morbidity and mortality, effective intraoperative cardiac protection primarily defines postoperative outcomes. Well studied techniques and recognized cardiac safety methods do have some drawbacks in their functions. One solution to this issue is increased metabolic assistance, intended to minimize perceived ischemic injury. In practical use, many modern techniques such as glucose insulin potassium infusion are still restricted in terms of their added efficacy in cardiac protection. Providing glucose and insulin to the critically ischaemic cell has been hypothesized to have several beneficial effects, it increases the production of anaerobic ATP despite the inhibition of fatty acid metabolism while retaining a defensive role on the threatened cell membrane. | ||||
| Keywords | ||||
| coronary artery bypass grafting (CABG); cardiac protection; GIK; myocardial injury | ||||
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