Effects of Mannan-oligosaccharide and β-Glucan Prebiotic on the Brain Oxidant/Antioxidant Balance in Broilers under Natural Egyptian Summer Conditions | ||||
| Egyptian Academic Journal of Biological Sciences, B. Zoology | ||||
| Article 4, Volume 10, Issue 1, June 2018, Page 35-46 PDF (498.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsz.2018.13428 | ||||
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| Authors | ||||
| Sohair M. M. Rageb1; Elham A. Abd-Allah2; Nasser S. Abou Khalil3; Fatma M. Abdel-Maksoud4; Usama T. Mahmoud5 | ||||
| 1Department of Zoology, Faculty of Science, Assiut University, Assiut, Egypt | ||||
| 2Department of Zoology, Faculty of Science-New Valley, Assiut University, Assiut, Egypt | ||||
| 3Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| 4Department of Anatomy & Histology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt | ||||
| 5Department of Animal Hygiene, Faculty of Veterinary Medicine, Assiut University, Egypt | ||||
| Abstract | ||||
| This study was conducted to investigate the potential effects of mannan-oligosaccharide (MOS) and β-glucan (BG) prebiotic (AGRIMOS®) on the redox homeostasis, histopathology, and microglia count in the brain of heat-stressed broiler chickens. One hundred sixty eight (168) Ross one-day-old broiler chicks were obtained from local hatchery. The experiment was started at 28-day old; where birds were exposed to heat stress and were randomly allotted to four dietary treatments containing 0 (control), 0.5, 2, and 4 g/kg MOS and BG probiotic, respectively, for 14 days. Each treatment consisted of three replicates of 14 birds each (i.e., total birds/treatment count is 42 birds). The results indicated a significant decrease in catalase and superoxide dismutase activities in all MOS and β-glucan prebiotic treated groups. Supplementation with 0.5 g of prebiotic/kg diet resulted in a significant increase in glutathione levels; however, a significant decrease in superoxide radicals was found at dose of 4 g of prebiotic/kg diet. The levels of lipid peroxidation in supplemented groups exhibited a significant decrease at doses of 2 and 4 g of prebiotic/kg diet. Although there were no obvious changes in the histoarchitecture of cerebellar tissues, a significant increase in the number of microglia was evident following administration with 4 g of prebiotic/kg diet. In conclusion, supplementation of MOS and BG may be regarded as promising candidate for alleviating the undesirable effects of heat challenge on the brain of broiler chickens, nevertheless; further studies are warranted to look for other nutritional approaches. | ||||
| Keywords | ||||
| prebiotic; broiler; heat stress; Brain; oxidant/antioxidant; microglia | ||||
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