Protective Effects of Androctonus Amoreuxi Scorpion Extract and Sitagliptin Treatment on The Liver Injury of Diabetic Rats
Khaled, H., Farrag, A., Othman, A., Tag, H. (2016). Protective Effects of Androctonus Amoreuxi Scorpion Extract and Sitagliptin Treatment on The Liver Injury of Diabetic Rats. EKB Journal Management System, 8(1), 99-108. doi: 10.21608/eajbsz.2016.13467
Howayda A. Khaled; Abdel Razik H. Farrag; Amal I. Othman; Hend M. Tag. "Protective Effects of Androctonus Amoreuxi Scorpion Extract and Sitagliptin Treatment on The Liver Injury of Diabetic Rats". EKB Journal Management System, 8, 1, 2016, 99-108. doi: 10.21608/eajbsz.2016.13467
Khaled, H., Farrag, A., Othman, A., Tag, H. (2016). 'Protective Effects of Androctonus Amoreuxi Scorpion Extract and Sitagliptin Treatment on The Liver Injury of Diabetic Rats', EKB Journal Management System, 8(1), pp. 99-108. doi: 10.21608/eajbsz.2016.13467
Khaled, H., Farrag, A., Othman, A., Tag, H. Protective Effects of Androctonus Amoreuxi Scorpion Extract and Sitagliptin Treatment on The Liver Injury of Diabetic Rats. EKB Journal Management System, 2016; 8(1): 99-108. doi: 10.21608/eajbsz.2016.13467

Protective Effects of Androctonus Amoreuxi Scorpion Extract and Sitagliptin Treatment on The Liver Injury of Diabetic Rats

Egyptian Academic Journal of Biological Sciences, B. Zoology
Article 9, Volume 8, Issue 1, August 2016, Page 99-108  XML PDF (1.27 MB)
Document Type: Original Article
DOI: 10.21608/eajbsz.2016.13467
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Authors
Howayda A. Khaled1; Abdel Razik H. Farrag2; Amal I. Othman3; Hend M. Tag4
1Zoology Department, Faculty of Science, Suez University
2Pathology Department, National Research Center
3Faculty of Science, Cairo University
4Zoology Department, Faculty of Science, Suez Canal University
Abstract
Liver injury is involved in both the pathogenesis and complications of diabetes. Androctonus Amoreuxi scorpion tea was previously reported to modulate physiological responses in streptozotocin-induced diabetic rats. This study attempts to evaluate liver protective effects of scorpion tea (Androctonus Amoreuxi) and sit agliptinin streptozotocin-induced diabetic rats. Forty rats were divided into four groups (n=10). Diabetes were induced in male albino rat by intraperitoneal injection of 65 mg/kg STZ. Three days later, the animals randomly divided to 3 groups: diabetic group, diabetic+ S.Tea(300 mg/kg )and diabetic+ ST (10 mg/kg ) besides control group received intraperitoneal injection of saline. Liver histological and biochemical markers, were monitored at the end of experimental peroid. Results of our study revealed that treatment with scorpion tea or sitagliptin produced significant liver protection manifested by a significant decrease in serum levels of alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamy-ltransferase (GGT) and lactate dehydrogenase (LDH).Histologically, liver of diabetic rats showed severe liver injury.  Histopathological changes were significantly attenuated in diabetic animals treated with scorpion tea or sitagliptin. Results of this study suggest that A. amoreuxi scorpion extract and sitagliptin have protective effects against hepatic injury.
Keywords
Androctonus Amoreuxi scorpion extract. Streptozotocin; diabetic rats
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