Influence of amprolium and toltrazuril on the disposition kinetics of levofloxacin in broiler chickens
A., E., H., E., Abd El Latif, A. (2013). Influence of amprolium and toltrazuril on the disposition kinetics of levofloxacin in broiler chickens. EKB Journal Management System, 5(2), 1-10. doi: 10.21608/eajbsz.2013.13499
El-Banna H. A.; El- Hewaity M. H.; Amera Abd El Latif. "Influence of amprolium and toltrazuril on the disposition kinetics of levofloxacin in broiler chickens". EKB Journal Management System, 5, 2, 2013, 1-10. doi: 10.21608/eajbsz.2013.13499
A., E., H., E., Abd El Latif, A. (2013). 'Influence of amprolium and toltrazuril on the disposition kinetics of levofloxacin in broiler chickens', EKB Journal Management System, 5(2), pp. 1-10. doi: 10.21608/eajbsz.2013.13499
A., E., H., E., Abd El Latif, A. Influence of amprolium and toltrazuril on the disposition kinetics of levofloxacin in broiler chickens. EKB Journal Management System, 2013; 5(2): 1-10. doi: 10.21608/eajbsz.2013.13499

Influence of amprolium and toltrazuril on the disposition kinetics of levofloxacin in broiler chickens

Egyptian Academic Journal of Biological Sciences, B. Zoology
Article 1, Volume 5, Issue 2, September 2013, Page 1-10  XML PDF (187.76 K)
Document Type: Original Article
DOI: 10.21608/eajbsz.2013.13499
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Authors
El-Banna H. A.1; El- Hewaity M. H.2; Amera Abd El Latif2
1Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University
2Department of Pharmacology, Faculty of Veterinary Medicine, El-Sadat City University
Abstract
The pharmacokinetic properties of levofloxacin alone and with amprolium or toltrazuril were determined in broiler chickens after a single IV and oral administrations. After IV injection, levofloxacin serum concentration was best to be described by a two-compartment open model. Amprolium resulted in a significance increase in Vdss and Cltot (3.05 ± 0.17 and 0.65 ± 0.023 L/kg, respectively). In contrast, toltrazuril induced a significance decrease in Vdss and Cltot (1.71 ± 0.17 and 0.32 ± 0.015 L/kg, respectively) compared with levofloxacin alone (2.36 ± 0.34 and 0.44±0.009 L /kg, respectively). The elimination half-life and the mean residence time of levofloxacin were 4.07 ± 0.24 and 5.40 ± 0.26, 3.89 ± 0.24 and 4.77 ± 0.28, 4.10 ± 0.45 and 5.38 ± 0.36 h. in control, amprolium and toltrazuril respectively. Following oral dosing the maximum serum concentration was 3.27 ± 0.13, 2.17 ± 0.097 and 2.95 ± 0.11 µg/ml reached at 1.32 ± 0.096, 0.92 ± 0.057 and 1.30 ± 0.037h in control, amprolium and toltrazuril respectively. Amprolium and toltrazuril resulted in a significance decrease in interval between doses (19.10 ± 0.58 and 19.29 ± 0.51h respectively), compared with levofloxacin alone (27.39 ± 1.80 h.). Oral bioavailability was found to be 107.47 ± 9.23, 75.74 ± 4.50 and 53.51 ± 2.45% in control, amprolium and toltrazuril respectively. It was concluded that the pretreatment of (amprolium and toltrazuril) with levofloxacin altered the pharmacokinetic profile of levofloxacin.
Keywords
amprolium – toltrazuril – levofloxacin; Broiler chickens
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